| Texto completo | |
| Autor(es): |
Xavier de Lima, Miguel Antonio
[1]
;
Baldo, Marcus Vinicius C.
[2]
;
Oliveira, Fernando A.
[3]
;
Canteras, Newton Sabino
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[3] Fed Univ ABC, Cellular & Mol Neurobiol Lab LaNeC, Ctr Math Comp & Cognit CMCC, Sao Bernardo Do Campo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | eLIFE; v. 11, JAN 5 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. The experiments were made in mice and revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits. (AU) | |
| Processo FAPESP: | 14/05432-9 - Bases neurais do medo e agressão |
| Beneficiário: | Newton Sabino Canteras |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/10389-0 - Investigação do envolvimento das áreas do córtex pré-frontal e de seus alvos no processamento da memória de medo: estudo com técnicas fármaco e optogenéticas |
| Beneficiário: | Miguel Antonio Xavier de Lima |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/27245-0 - Relação entre dinâmica de ATP intracelular e modulação da concentração de cálcio citosólico no neurônio |
| Beneficiário: | Fernando Augusto de Oliveira Ribeiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |