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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats

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Author(s):
Xavier de Lima, Miguel Antonio [1] ; Baldo, Marcus Vinicius C. [2] ; Oliveira, Fernando A. [3] ; Canteras, Newton Sabino [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[3] Fed Univ ABC, Cellular & Mol Neurobiol Lab LaNeC, Ctr Math Comp & Cognit CMCC, Sao Bernardo Do Campo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: eLIFE; v. 11, JAN 5 2022.
Web of Science Citations: 0
Abstract

Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. The experiments were made in mice and revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits. (AU)

FAPESP's process: 14/05432-9 - Neural bases of fear and aggression
Grantee:Newton Sabino Canteras
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/10389-0 - Involvement of prefrontal cortex areas and their targets in fear memory processing: a study with drug and optogenetic techniques
Grantee:Miguel Antonio Xavier de Lima
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/27245-0 - Relationship between intracellular ATP dynamics and modulation of cytosolic calcium concentration in the neuron
Grantee:Fernando Augusto de Oliveira Ribeiro
Support Opportunities: Regular Research Grants