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Signaling pathways involved in fear memory to predatory threats

Grant number: 15/23092-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2016
Effective date (End): September 30, 2018
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Newton Sabino Canteras
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:14/05432-9 - Neural bases of fear and aggression, AP.TEM
Associated scholarship(s):17/08668-1 - In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat, BE.EP.PD

Abstract

The aim of the project is to investigate the signaling paths involved in fear memory to predatory threats. Signaling paths related to corticosteroids, noradrenaline and glutamate are good candidates to be involved in mediating plastic changes in neurons in the lateral amygdala, a critical site to store fear memory. Moreover, previous studies have also shown the involvement of mTOR (mammalian target of rapamycin) - as involved in controlling protein synthesis related to memory acquisition - and the PKMzeta - as related to the stabilization of memory processing. In the present study, we shall investigate the involvement of the signaling paths related to NMDA, glucocorticoids and beta-adrenergic receptors, as well as the potential role of mTOR and PKMzeta in memory processing of predator-related fear. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZHANG, ZHI; REIS, FERNANDO M. C. V.; HE, YANLIN; PARK, JAE W.; DIVITTORIO, JOHNATHON R.; SIVAKUMAR, NILLA; VAN VEEN, J. EDWARD; MAESTA-PEREIRA, SANDRA; SHUM, MICHAEL; NICHOLS, INDIA; MASSA, MEGAN G.; ANDERSON, SHAWN; PAUL, KETEMA; LIESA, MARC; AJIJOLA, OLUJIMI A.; XU, YONG; ADHIKARI, AVISHEK; CORREA, STEPHANIE M. Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice. NATURE COMMUNICATIONS, v. 11, n. 1 DEC 11 2020. Web of Science Citations: 1.
SCHUETTE, PETER J.; REIS, V, FERNANDO M. C.; MAESTA-PEREIRA, SANDRA; CHAKERIAN, MEGHMIK; TOROSSIAN, ANITA; BLAIR, GARRETT J.; WANG, WEISHENG; BLAIR, HUGH T.; FANSELOW, MICHAEL S.; KAO, JONATHAN C.; ADHIKARI, AVISHEK. Long-Term Characterization of Hippocampal Remapping during Contextual Fear Acquisition and Extinction. JOURNAL OF NEUROSCIENCE, v. 40, n. 43, p. 8329-8342, OCT 21 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.