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High intensity sound stimulation and synaptic plasticity

Abstract

The limbic system is affected by sensory stimuli, including stimulation from the auditory system. Not only, neurons and synapses from regions like the hippocampus and the amygdala can be affected by auditory stimulation and some pathologies of the auditory system caused by acoustic trauma, as for example tinnitus, have a strong limbic component. Recently we demonstrated that chronic high-intensity auditory stimulation inhibits long-term potentiation in the Schaffer-CA1 hippocampal pathway in rats, without affecting spatial learning and memory (Cunha et al., 2105). In this project we propose to investigate the mechanisms underlying this effect and the effect of the acute auditory stimulation, the effect on auditory synapses and the implementation of optogenetics tools which will help in the investigation of this and other related phenomena. Because of the increasing exposition to loud sounds in the modern urban life, both caused by environmental, occupational and recreational causes, and to the impact in the auditory and emotional health that the acoustic stress can promote, to understand the mechanisms that link the auditory and limbic system are important for the comprehension of the physiological substrates of the pathologies caused by acoustic stress. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE DEUS, J. L.; CUNHA, A. O. S.; TERZIAN, A. L.; RESSTEL, L. B.; ELIAS, L. L. K.; ANTUNES-RODRIGUES, J.; ALMEIDA, S. S.; LEAO, R. M.. A single episode of high intensity sound inhibits long-term potentiation in the hippocampus of rats. SCIENTIFIC REPORTS, v. 7, . (16/01607-4)
SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; CEBALLOS, CESAR CELIS; DE DEUS, JUNIA LARA; DE OLIVEIRA PENA, RODRIGO FELIPE; CORTES DE OLIVEIRA, JOSE ANTONIO; ROQUE, ANTONIO CARLOS; GARCIA-CAIRASCO, NORBERTO; LEAO, RICARDO MAURICIO. Intrinsic and synaptic properties of hippocampal CA1 pyramidal neurons of the Wistar Audiogenic Rat (WAR) strain, a genetic model of epilepsy. SCIENTIFIC REPORTS, v. 8, . (15/50122-0, 16/01607-4, 15/22327-7, 13/07699-0)
STRAZZA, JR., PAULO S.; DE SIQUEIRA, DANIELA V. F.; LEAO, RICARDO M.. ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 5, . (19/13458-1, 16/01607-4)
DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; GAMA DE BARCELLOS FILHO, PROCOPIO CLEBER; CORTES DE OLIVEIRA, JOSE ANTONIO; BATALHAO, MARCELO EDUARDO; GARCIA-CAIRASCO, NORBERTO; CARNIO, EVELIN CAPELLARI; LEAO, RICARDO MAURICIO; DE SIQUEIRA BRANCO, LUIZ GUILHERME; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO. Inflammatory markers in the hippocampus after audiogenic kindling. Neuroscience Letters, v. 721, . (17/09878-0, 15/22327-7, 16/01607-4, 16/17681-9)
SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; MORADI, MARZIEH; DE DEUS, JUNIA LARA; CEBALLOS, CESAR CELIS; MOREIRA BENITES, NIKOLLAS; GAMA DE BARCELLOS FILHO, PROCOPIO CLEBER; CORTES DE OLIVEIRA, JOSE ANTONIO; GARCIA-CAIRASCO, NORBERTO; LEAO, RICARDO. Alterations in brainstem auditory processing, the acoustic startle response and sensorimotor gating of startle in Wistar audiogenic rats (WAR), an animal model of reflex epilepsies. Brain Research, v. 1727, . (15/22327-7, 16/01607-4)
DE DEUS, JUNIA L.; AMORIM, MATEUS R.; RIBEIRO, ALINE B.; BARCELLOS-FILHO, PROCOPIO C. G.; CEBALLOS, CESAR C.; BRANCO, LUIZ GUILHERME S.; CUNHA, ALEXANDRA O. S.; LEAO, RICARDO M.. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and Molecular Neurobiology, v. 41, n. 4, . (16/17681-9, 15/22327-7, 16/01607-4)
PENA, RODRIGO F. O.; CEBALLOS, CESAR CELIS; DE DEUS, JUNIA LARA; ROQUE, ANTONIO CARLOS; GARCIA-CAIRASCO, NORBERTO; LEAO, RICARDO MAURICIO; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO. Modeling Hippocampal CA1 Gabaergic Synapses of Audiogenic Rats. International Journal of Neural Systems, v. 30, n. 5, . (15/22327-7, 13/07699-0, 15/50122-0, 16/01607-4, 13/25667-8)
CUNHA, ALEXANDRA O. S.; DE DEUS, JUNIA L.; CEBALLOS, CESAR C.; LEAO, RICARDO M.. Increased hippocampal GABAergic inhibition after long-term high-intensity sound exposure. PLoS One, v. 14, n. 5, . (15/22327-7, 16/01607-4)
MURAT, CAHUE DE BERNARDIS; LEAO, RICARDO MAURICIO. A voltage-dependent depolarization induced by low external glucose in neurons of the nucleus of the tractus solitarius: interaction with K-ATP channels. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 9, p. 2515-2532, . (16/01607-4)
SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; CEBALLOS, CESAR CELIS; DE DEUS, JUNIA LARA; LEAO, RICARDO MAURICIO. Long-term high-intensity sound stimulation inhibits h current (I-h) in CA1 pyramidal neurons. European Journal of Neuroscience, v. 47, n. 11, p. 1401-1413, . (16/01607-4, 15/22327-7)
CEBALLOS, CESAR C.; ROQUE, ANTONIO C.; LEAO, RICARDO M.. A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations. BIOPHYSICAL JOURNAL, v. 113, n. 10, p. 2207-2217, . (16/01607-4, 13/07699-0)

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