Hemodynamic Effects of Different Combinations of Midazolam and Opioids in Healthy Dogs

Autor(es)

Ferreira, Mariana de Andrade ^[1] ; Possidonio, Geovana ^[1] ; Afonso, Caroliny Santos ^[1] ; Ribeiro, Ingrid Volpe ^[1] ; Moreira, Talita F. ^[2] ; Marques, Marcel Gambin ^[2] ; Xavier Abimussi, Caio Jose ^[2] ; Floriano, Beatriz Perez ^[2]

Afiliação do(s) autor(es)

^[1] Univ Ctr Integrated Fac Ourinhos Unifio, Roque Quagliato Vet Hosp, Ourinhos, SP - Brazil

^[2] Univ Ctr Integrated Fac Ourinhos Unifio, Dept Vet Med, Ourinhos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TOPICS IN COMPANION ANIMAL MEDICINE; v. 46, JAN-FEB 2022.
• Citações Web of Science: 0

Resumo

The purpose of this study was to compare the hemodynamic effects of four different combinations of midazolam and opioids in healthy dogs. Twenty-four healthy dogs were divided in four groups (n = 6) using intramuscular midazolam 0.3 mg/kg and morphine 0.3 mg/kg (GMOR), methadone 0.3 mg/kg (GMET), butorphanol 0.2 mg/kg (GBUT) or fentanyl 5 ug/kg (GFEN). Cardiovascular variables were recorded before (TB) and 20 minutes following drug administration (T20) and comprised arterial blood pressure, heart rate and cardiac index. Subsequently, left ventricular work index and total peripheral resistance index were calculated using the previous variables. At the end of the study, data were compared using analysis of variance followed by Tukey test and Friedman followed by Dunn test, all under 5% significance. No differences were found on cardiovascular variables at all times among the groups, which indicates that all combinations provide hemodynamic stability for clinical sedation of healthy dogs. However, a few animals showed paradoxical excitation in GBUT. In conclusion, the association of midazolam with morphine, methadone, butorphanol or fentanyl provides cardiovascular stability and can be used to sedate dogs undergoing cardiovascular examination, although caution is warranted with the use of midazolam with butorphanol due to possible paradoxical excitation. (c) 2021 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/11947-2 - Efeitos hemodinâmicos e eletrocardiográficos de diferentes combinações de midazolam e opióides em cães saudáveis
• Beneficiário: Mariana de Andrade Ferreira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica