Microfluidics as a tool to assess and induce emulsion destabilization

Autor(es)

Santos, Tatiana Porto ^{[1, 2]} ; Cejas, Cesare M. ^{[3, 4]} ; Cunha, Rosiane Lopes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Food Engn, Dept Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas - Brazil

^[2] Okinawa Inst Sci & Technol Grad Univ, Onna Son, Okinawa 9040495 - Japan

^[3] PSL Res Univ, Inst Pierre Gilles Gennes IPGG, ESPCI Paris, UMR 8231, Microfluid, MEMS, Nanostruct Lab, CNRS Chim Biol Inn, 6 Rue Jean Calvin, F-75005 Paris - France

^[4] MicrofluidX Ltd, Stevenage Biosci Catalyst, Gunnels Wood Rd, Stevenage SG1 2FX, Herts - England

• Tipo de documento: Artigo de Revisão
• Fonte: SOFT MATTER; v. 18, n. 4, p. 698-710, JAN 26 2022.
• Citações Web of Science: 0

Resumo

Microfluidic technology enables judicious control of the process parameters on a small length scale, which in turn allows speeding up the destabilization of emulsion droplets interface in microfluidic devices. In this light, microfluidic channels can be used as an efficient tool to assess emulsion stability and to observe the behavior of the droplets immediately after their formation, enabling to determine whether or not they are prone to re-coalescence. Observation of the droplets after emulsifier adsorption also allows the investigation of emulsion stability over time. Both evaluations would contribute to determine emulsion stability aiming at specific applications in food and pharmaceutical industries. Furthermore, emulsion coalescence can also be performed under extremely controlled conditions within the microfluidic devices in order to explore emulsion droplets as micro-reactors (for regulated biological and chemical assays). Such microfluidic procedures can be performed either in confined environments or under dynamic flow conditions. Under confined environments, droplets are observed in fixed positions simulating different environmental conditions. On the other hand, with the scrutiny of emulsions under dynamic flow processes, it is possible to determine the behavior of the droplets when subjected to shear forces, comparable to those experienced in conventional emulsification techniques or even in pumping operations. Given the above, this paper reviews different microfluidic techniques (such as changing channel geometry or wettability) hitherto used to destabilize emulsions, mainly focusing on the specificities of each study, whether the droplets are destabilized in confined or dynamic flow processes. Thereby, by going deeper into this review, readers will be able to identify different strategies for emulsion destabilization (in order to understand stabilizing mechanisms or even to apply these droplets as micro-reactors), as this paper shows the particularities of the most recent studies and elucidates the current state-of-the-art of this microfluidic-related application. (AU)

• Processo FAPESP: 17/18109-0 - Desenvolvimento de um analisador de estabilidade de emulsões utilizando microfluídica
• Beneficiário: Tatiana Porto dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/07744-1 - Utilização de dispositivos microfluídicos para avaliação de estabilidade de emulsões
• Beneficiário: Rosiane Lopes da Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Regular