razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode

Autor(es)

Paula, Lucas A. de L. ^[1] ; Santos, Mario F. C. ^[1] ; Pagotti, Mariana C. ^[1] ; Veneziani, Rodrigo C. S. ^[1] ; Bastos, Jairo K. ^[2] ; Caffrey, Conor R. ^[3] ; Ambrosio, Sergio R. ^[1] ; Magalhaes, Lizandra G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Ctr Res Sci & Technol, Res Grp Nat Prod, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, BR-040903 Ribeirao Preto, SP - Brazil

^[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Ctr Discovery & Innovat Parasit Dis, 9500 Gilman Dr, La Jolla, CA 92093 - USA

• Tipo de documento: Artigo Científico
• Fonte: Parasitology Research; v. 121, n. 2, p. 775-780, FEB 2022.
• Citações Web of Science: 0

Resumo

Characterized as an acute and chronic parasitic disease, schistosomiasis mansoni has as its central pathology the formation of hepatic granulomas in response to the parasite's eggs trapped in the host's liver. In recent years, research on propolis has grown; however, there is little anthelmintic work on this bee product. In the propolis scenario, Brazilian ones receive attention, with green and red propolis standing out. This study aims to evaluate in vivo the standardized extract of Brazilian green propolis (Pex) against Schistosoma mansoni. The in vivo antiparasitic activity of Pex was conducted in female BALB/c mice infected with S. mansoni and of the three groups treated with Pex (300 mg/kg); G2 (35th to 42nd dpi) reduced the total worm burden by 55.32%, followed by G3 (42nd to 49th dpi) and G4 (49th to 56th dpi), with about 46%. Furthermore, G2 significantly reduced the total egg load in the ileum (59.33%) and showed an increase in the dead eggs. Similarly, histological analysis of the livers showed a significant reduction in the number and diameter of the granulomas. Based on these results, there is an interesting schistosomicidal activity of Pex and its potential against the formation of hepatic granulomas, paving the way for more detailed studies of propolis in the animal model of schistosomiasis mansoni. (AU)

• Processo FAPESP: 18/50011-2 - Exploring turmeric curcuminoids to treat schistosomiasis: an evaluation of their pre-clinical potential
• Beneficiário: Lizandra Guidi Magalhães
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/25010-2 - Isolamento e identificação de componentes químicos das própolis marrom e verde.
• Beneficiário: Mário Ferreira Conceição Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/05080-6 - EMU concedido no processo 2017/04138-8 para sistema de cromatografia líquida de alta pressão semipreparativo modelo LC-20AR
• Beneficiário: Sergio Ricardo Ambrosio
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários