Birth weight and its relationship with endothelial function and pattern of endothelium-derived microparticles during childhood: New insight about early vascular damage

Autor(es)

Parizotto, Giovanna Pachele ; de Souza, Livia Victorino ; Thomazini, Fernanda ; Prado, Monica Simon ; Henao Agudelo, Juan Sebastian ; de Almeida, Danilo Candido ; Franco, Maria do Carmo

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 298, p. 8-pg., 2022-06-01.

Resumo

Aims: To investigate whether a specific endothelium-derived microparticles (EMPs) phenotype could be associated with birth weight and microvascular endothelial function in children.& nbsp;Materials and methods: A total of 95 children aged 6-14 years were recruited. Anthropometric measurements, blood pressure measurement, microvascular endothelial function testing, and biochemical profile analyses were performed. Standardized flow cytometry methods were used to identify and quantify the circulating CD144+, CD31+/annexin V+, and CD62E+ EMPs.& nbsp;Key findings: The circulating number of CD31+/annexin V+ EMPs and CD144+ EMP levels were correlated with birth weight, systolic blood pressure, microvascular endothelial function, total cholesterol, and low-density lipoprotein cholesterol (LDL-C) level. In the multivariable logistic regression models, we identified strong evidence of a higher risk of microvascular endothelial dysfunction among children with low birth weight (LBW) and increased levels of both CD31+/annexin V+ EMPs and LDL-C; LBW and elevated LDL-C levels were independent predictors of high circulating numbers of CD31+/annexin V+ and CD144+ > 75th percentile EMPs.& nbsp;Significance: Our data provide evidence that children with LBW values showed greater numbers of circulating CD31+/annexin V+ and CD144+ EMPs. In addition, LBW and high levels of CD31+/annexin V+ and LDL-C were significant risk factors for the presence of microvascular endothelial dysfunction.& nbsp; (AU)

• Processo FAPESP: 18/04013-3 - Quantificação da população de micropartículas de origem endotelial circulantes e análise do seu perfil de miRNAs: avaliação do impacto sobre a inter-relação entre o peso ao nascer, níveis pressóricos e função endotelial em crianças de 6 a 12 anos
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular