| Full text | |
| Author(s): |
Parizotto, Giovanna Pachele
;
de Souza, Livia Victorino
;
Thomazini, Fernanda
;
Prado, Monica Simon
;
Henao Agudelo, Juan Sebastian
;
de Almeida, Danilo Candido
;
Franco, Maria do Carmo
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Life Sciences; v. 298, p. 8-pg., 2022-06-01. |
| Abstract | |
Aims: To investigate whether a specific endothelium-derived microparticles (EMPs) phenotype could be associated with birth weight and microvascular endothelial function in children.& nbsp;Materials and methods: A total of 95 children aged 6-14 years were recruited. Anthropometric measurements, blood pressure measurement, microvascular endothelial function testing, and biochemical profile analyses were performed. Standardized flow cytometry methods were used to identify and quantify the circulating CD144+, CD31+/annexin V+, and CD62E+ EMPs.& nbsp;Key findings: The circulating number of CD31+/annexin V+ EMPs and CD144+ EMP levels were correlated with birth weight, systolic blood pressure, microvascular endothelial function, total cholesterol, and low-density lipoprotein cholesterol (LDL-C) level. In the multivariable logistic regression models, we identified strong evidence of a higher risk of microvascular endothelial dysfunction among children with low birth weight (LBW) and increased levels of both CD31+/annexin V+ EMPs and LDL-C; LBW and elevated LDL-C levels were independent predictors of high circulating numbers of CD31+/annexin V+ and CD144+ > 75th percentile EMPs.& nbsp;Significance: Our data provide evidence that children with LBW values showed greater numbers of circulating CD31+/annexin V+ and CD144+ EMPs. In addition, LBW and high levels of CD31+/annexin V+ and LDL-C were significant risk factors for the presence of microvascular endothelial dysfunction.& nbsp; (AU) | |
| FAPESP's process: | 18/04013-3 - Quantification of the endothelial microparticles and analysis of the miRNA profile: evaluation of the impact on the interrelation between birth weight, blood pressure levels and endothelial function in children from 6 to 12 years of age |
| Grantee: | Maria Do Carmo Pinho Franco |
| Support Opportunities: | Regular Research Grants |