Approaches to advance drug discovery for neglected tropical diseases

Autor(es)

Ferreira, Leonardo L. G. ; de Moraes, Josue ; Andricopulo, Adriano D.

• Tipo de documento: Artigo Científico
• Fonte: DRUG DISCOVERY TODAY; v. 27, n. 8, p. 10-pg., 2022-08-01.

Resumo

Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in developing countries, as highlighted in the 2021-2030 WHO Roadmap on NTDs. This agenda sets the challenges for the control and elimination of NTDs by 2030. Fortunately, NTD drug discovery has shifted from traditional to modern strategies combining medicinal chemistry, phenotypic and molecular assays, multiparameter optimization, structural biology, and omics approaches. Structure-and ligand-based drug design have fostered NTD drug discovery by enabling data-driven molecular optimization, expansion to previously inaccessible chemical spaces, and knowledge building from biological data. These efforts have integrated parasite biology and medicinal chemistry to advance drug discovery in this key area of global health. (AU)

• Processo FAPESP: 20/01441-4 - Seleção de fármacos com atividade anti-helmíntica, nanoencapsulação e avaliação pré-clínica em modelo experimental de esquistossomose
• Beneficiário: Josué de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs