Intestinal Microbiota in the SARS-CoV-2 Infection: What Is Known?

Autor(es)

Rodrigues, Patricia Brito ; Dos Santos Pereira Gomes, Arilson Bernardo ; Genaro, Livia Moreira ; Pascoal, Livia Bitencourt ; Duarte De Souza, Ana Paula ; Leal, Raquel Franco ; Ramirez Vinolo, Marco Aurelio ; Guest, PC

• Tipo de documento: Artigo Científico
• Fonte: IDENTIFCATION OF BIOMARKERS, NEW TREATMENTS, AND VACCINES FOR COVID-19; v. 1327, p. 14-pg., 2021-01-01.

Resumo

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, emerged last year in China and quickly spread to millions of people around the world. This virus infects cells in different tissues and causes pulmonary (e.g., pneumonia and acute respiratory distress syndrome), neurological, cardiovascular, and intestinal manifestations, which can be the result of a direct viral effect or secondary to endothelial, thrombotic, or immunological alterations. In this chapter, we discuss recent studies which highlighted the relevance of the intestinal microbiota for other infectious respiratory diseases. We present the "altered microbiota" (dysbiotic) as a point of connection between conditions that are risk factors for the development of severe forms of COVID-19. In addition, we describe the findings of recent studies reporting alterations of microbiota composition in COVID-19 patients and speculate on how this may impact in development of the disease. (AU)

• Processo FAPESP: 20/02312-3 - Estudo do efeito dos ácidos graxos de cadeia curta no processo de regeneração tecidual durante a colite experimental
• Beneficiário: Arilson Bernardo dos Santos Pereira Gomes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/04583-4 - Impacto da microbiota intestinal e seus metabólitos na infecção por SARS-CoV-2
• Beneficiário: Marco Aurélio Ramirez Vinolo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/14342-7 - Comparação do tropismo e patogenicidade da variante gama versus SARS Cov-2 original em camundongos K18-ACE2 humanizado: papel da microbiota intestinal
• Beneficiário: Patrícia Brito Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Doutorado