Peroxisome proliferator-activated receptor-gamma (PPAR gamma) and its immunomodulation function: current understanding and future therapeutic implications

Autor(es)

Trindade da Silva, Carlos Antonio ; Clemente-Napimoga, Juliana Trindade ; Abdalla, Henrique Ballassini ; Basting, Rosanna Tarkany ; Henrique Napimoga, Solely Marcelo

• Tipo de documento: Artigo Científico
• Fonte: EXPERT REVIEW OF CLINICAL PHARMACOLOGY; v. 15, n. 3, p. 9-pg., 2022-05-02.

Resumo

Introduction: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact. Areas covered: Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It regulates several metabolic pathways, including lipid biosynthesis and glucose metabolism, when activated. However, PPAR gamma activation also has a critical immunomodulatory and neuroprotective effect. Expert opinion: This review summarizes the evidence of synthetic or natural PPAR gamma ligands such as 15d-PGJ(2), epoxyeicosatrienoic acids, thiazolidinediones, and specialized pro-resolving mediators, representing an interesting therapeutic tool for pain control. (AU)

• Processo FAPESP: 19/01151-9 - Avaliação do efeito imunomodulador e neuroprotetor do inibidor de epóxi hidrolase, TPPU, na hipernocicepção inflamatória persistente induzida pela artrite na articulação temporomandibular de ratos.
• Beneficiário: Carlos Antonio Trindade da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/22334-9 - Uso de sistemas de liberação de fármacos para o desenvolvimento e aplicabilidade de agentes anti-inflamatórios com potencial efeito imunomodulador e neuroprotetor
• Beneficiário: Marcelo Henrique Napimoga
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/04276-7 - O uso de microagulhas revestíveis com fármacos para o controle de da dor e inflamação
• Beneficiário: Henrique Ballassini Abdalla
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado