| Full text | |
| Author(s): |
Trindade da Silva, Carlos Antonio
;
Clemente-Napimoga, Juliana Trindade
;
Abdalla, Henrique Ballassini
;
Basting, Rosanna Tarkany
;
Henrique Napimoga, Solely Marcelo
Total Authors: 5
|
| Document type: | Journal article |
| Source: | EXPERT REVIEW OF CLINICAL PHARMACOLOGY; v. 15, n. 3, p. 9-pg., 2022-05-02. |
| Abstract | |
Introduction: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact. Areas covered: Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It regulates several metabolic pathways, including lipid biosynthesis and glucose metabolism, when activated. However, PPAR gamma activation also has a critical immunomodulatory and neuroprotective effect. Expert opinion: This review summarizes the evidence of synthetic or natural PPAR gamma ligands such as 15d-PGJ(2), epoxyeicosatrienoic acids, thiazolidinediones, and specialized pro-resolving mediators, representing an interesting therapeutic tool for pain control. (AU) | |
| FAPESP's process: | 19/01151-9 - Evaluation of the immunomodulatory and neuroprotective effect of the epoxy hydrolase inhibitor, TPPU, on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint of rats. |
| Grantee: | Carlos Antonio Trindade da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/22334-9 - Use of drug delivery systems for the development and application of anti-inflammatory agents with potential immunomodulatory and neuroprotective effects |
| Grantee: | Marcelo Henrique Napimoga |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/04276-7 - The use of micro-needles coated with drugs for the control of pain and inflammation |
| Grantee: | Henrique Ballassini Abdalla |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |