Peroxisome proliferator-activated receptor-gamma (PPAR gamma) and its immunomodulation function: current understanding and future therapeutic implications

Author(s)

Trindade da Silva, Carlos Antonio ; Clemente-Napimoga, Juliana Trindade ; Abdalla, Henrique Ballassini ; Basting, Rosanna Tarkany ; Henrique Napimoga, Solely Marcelo

• Document type: Journal article
• Source: EXPERT REVIEW OF CLINICAL PHARMACOLOGY; v. 15, n. 3, p. 9-pg., 2022-05-02.

Abstract

Introduction: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact. Areas covered: Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It regulates several metabolic pathways, including lipid biosynthesis and glucose metabolism, when activated. However, PPAR gamma activation also has a critical immunomodulatory and neuroprotective effect. Expert opinion: This review summarizes the evidence of synthetic or natural PPAR gamma ligands such as 15d-PGJ(2), epoxyeicosatrienoic acids, thiazolidinediones, and specialized pro-resolving mediators, representing an interesting therapeutic tool for pain control. (AU)

• FAPESP's process: 19/01151-9 - Evaluation of the immunomodulatory and neuroprotective effect of the epoxy hydrolase inhibitor, TPPU, on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint of rats.
• Grantee: Carlos Antonio Trindade da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/22334-9 - Use of drug delivery systems for the development and application of anti-inflammatory agents with potential immunomodulatory and neuroprotective effects
• Grantee: Marcelo Henrique Napimoga
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/04276-7 - The use of micro-needles coated with drugs for the control of pain and inflammation
• Grantee: Henrique Ballassini Abdalla
• Support Opportunities: Scholarships in Brazil - Post-Doctoral