Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control

Autor(es)

dos Santos, Guilherme Senna ; Miyasato, Patricia Aoki ; Stein, Erika Mattos ; Colepicolo, Pio ; Wright, Anthony D. ; de Braganca Pereira, Carlos Alberto ; Falkenberg, Miriam ; Nakano, Eliana

• Tipo de documento: Artigo Científico
• Fonte: MARINE DRUGS; v. 20, n. 2, p. 10-pg., 2022-02-01.

Resumo

Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (-)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos. (AU)

• Processo FAPESP: 17/07346-0 - Estudo de análogos baseados em produtos naturais de algas marinhas do gênero Laurencia (Rhodophyta, Ceramiales) para o controle de doenças tropicais negligenciadas
• Beneficiário: Erika Mattos Stein
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/06931-4 - Biodiversidade e prospecção de algas de águas tropicais e da Antártica marítima
• Beneficiário: Pio Colepicolo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 16/16223-7 - Planejamento e síntese de compostos bioativos originados de algas marinhas para combater a esquistossomose
• Beneficiário: Eliana Nakano
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular