CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

Autor(es)

Almeida, Renata Sanches ; Wisnieski, Fernanda ; Real Karia, Bruno Takao ; Cardoso Smith, Marilia Arruda

• Tipo de documento: Artigo Científico
• Fonte: GENES; v. 13, n. 11, p. 13-pg., 2022-11-01.

Resumo

Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research. (AU)

• Processo FAPESP: 16/25562-0 - Abordagem molecular e funcional no câncer gástrico da população brasileira
• Beneficiário: Marilia de Arruda Cardoso Smith
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/20592-6 - INVESTIGAÇÃO DE miRNAS DIFERENCIALMENTE EXPRESSOS EM SORO DE PACIENTES COM ADENOCARCINOMA GÁSTRICO
• Beneficiário: Bruno Takao Real Karia
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado