The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela

Autor(es):Mostrar menos -

Viala, Vincent Louis ; Slavov, Svetoslav Nanev ; Oliveira de Lima, Loyze Paola ; Jeronimo Lima, Alex Ranieri ; Ribeiro, Gabriela ; Martins, Antonio Jorge ; Petry, Bruna ; Banho, Cecilia Artico ; Dos Santos Barros, Claudia Renata ; Moncau, Cristina Tschorny ; Moretti, Debora Botequio ; Lima de la-Roque, Debora Glenda ; Marqueze, Elaine Cristina ; Mattos, Elisangela Chicaroni ; da Silva da Costa, Felipe Allan ; Fukumasu, Heidge ; Todao Bernardino, Jardelina de Souza ; Souza-Neto, Jayme A. ; Chagas Lesbon, Jessika Cristina ; Kayanoki, Lara Passos ; Bernardo, Leandro Lombo ; Sacchetto, Livia ; Clemente, Luan Gaspar ; Junior Alcantara, Luiz Carlos ; Coutinho, Luiz Lehmann ; Marques, Beatriz de Carvalho ; Giovanetti, Marta ; Nogueira, Mauricio Lacerda ; Poleti, Mirele Daiana ; Assato, Patricia Akemi ; Cattony Neto, Pedro de Queiroz ; Rocha Campos Cassano, Raquel de Lello ; Neto, Raul Machado ; Tommasini Grotto, Rejane Maria ; Brassaloti, Ricardo Augusto ; Kashima, Simone ; Covas, Dimas Tadeu ; Elias, Maria Carolina ; Sampaio, Sandra Coccuzzo

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 14, n. 7, p. 9-pg., 2022-07-01.

Resumo

Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (Sao Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations. (AU)

• Processo FAPESP: 20/10127-1 - Desenvolvimento de vacina contra a COVID-19
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas
• Processo FAPESP: 20/06441-2 - aplicação dos recursos da Reserva Técnica Institucional para melhoria das atividades de pesquisa do Instituto Butantan.
• Beneficiário: Sandra Coccuzzo Sampaio Vessoni
• Modalidade de apoio: Auxílio à Pesquisa - Reserva Técnica para Infraestrutura Institucional de Pesquisa
• Processo FAPESP: 18/15826-5 - Avaliação do impacto de vírus emergentes e re-emergentes em hemoterapia e transplante de células-tronco por meio de técnicas moleculares avançadas
• Beneficiário: Svetoslav Nanev Slavov
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores