| Texto completo | |
| Autor(es): |
Lima, Tanes
;
Li, Terytty Yang
;
Mottis, Adrienne
;
Auwerx, Johan
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE AGING; v. 2, n. 3, p. 15-pg., 2022-03-01. |
| Resumo | |
Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental responses during aging. We describe recent evidence arguing that defects in these conserved adaptive pathways contribute to aging and age-related diseases. Signaling pathways regulating the mitochondrial unfolded protein response, mitochondrial membrane dynamics, and mitophagy are discussed, emphasizing how their failure contributes to heteroplasmy and de-regulation of key metabolites. Our current understanding of how these processes are controlled and interconnected explains how mitochondria can widely impact fundamental aspects of aging. (AU) | |
| Processo FAPESP: | 19/11171-7 - Plataforma de triagem para a identificação de alvos moleculares envolvidos na homeostase mitocondrial |
| Beneficiário: | Tanes Imamura de Lima |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |