| Texto completo | |
| Autor(es): Mostrar menos - |
Ornelas, Isis M.
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Cini, Felipe A.
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Wiessner, Isabel
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Marcos, Encarni
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Araujo, Draulio B.
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Goto-Silva, Livia
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Nascimento, Juliana
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Silva, Sergio R. B.
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Costa, Marcelo N.
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Falchi, Marcelo
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Olivieri, Rodolfo
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Palhano-Fontes, Fernanda
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Sequerra, Eduardo
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Martins-de-Souza, Daniel
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Feilding, Amanda
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Renno-Costa, Cesar
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Tofoli, Luis Fernando
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Rehen, Stevens K.
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Ribeiro, Sidarta
Número total de Autores: 19
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| Tipo de documento: | Artigo Científico |
| Fonte: | Experimental Neurology; v. 356, p. 14-pg., 2022-07-12. |
| Resumo | |
The therapeutic use of classical psychedelic substances such as d-lysergic acid diethylamide (LSD) surged in recent years. Studies in rodents suggest that these effects are produced by increased neural plasticity, including stimulation of the mTOR pathway, a key regulator of metabolism, plasticity, and aging. Could psychedelic -induced neural plasticity be harnessed to enhance cognition? Here we show that LSD treatment enhanced per-formance in a novel object recognition task in rats, and in a visuo-spatial memory task in humans. A proteomic analysis of human brain organoids showed that LSD affected metabolic pathways associated with neural plas-ticity, including mTOR. To gain insight into the relation of neural plasticity, aging and LSD-induced cognitive gains, we emulated the experiments in rats and humans with a neural network model of a cortico-hippocampal circuit. Using the baseline strength of plasticity as a proxy for age and assuming an increase in plasticity strength related to LSD dose, the simulations provided a good fit for the experimental data. Altogether, the results suggest that LSD has nootropic effects. (AU) | |
| Processo FAPESP: | 14/10068-4 - EMU concedido no processo 13/08711-3: espectrômetro de massas Waters SYNAPT G2-Si HDMs + nanoACQUITY UPLC |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 17/25588-1 - Da compreensão básica a biomarcadores clínicos para a esquizofrenia: um estudo multidisciplinar centrado na neuroproteômica |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat |
| Beneficiário: | Oswaldo Baffa Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 19/00098-7 - EMU concedido no processo 2017/25588-1: cromatógrafo Acquity UPLC I-Class |
| Beneficiário: | Daniel Martins-de-Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |