Lower paraoxonase 1 paraoxonase activity is associated with a worse prognosis in patients with non-ST-segment elevation myocardial infarction in long-term follow-up

Autor(es)

Lacerda Leocadio, Paola Caroline ; Goulart, Alessandra Carvalho ; Santos, Itamar Souza ; Lotufo, Paulo Andrade ; Bensenor, Isabela Martins ; Alvarez-Leite, Jacqueline Isaura

• Tipo de documento: Artigo Científico
• Fonte: Coronary Artery Disease; v. 33, n. 7, p. 8-pg., 2022-11-01.

Resumo

Background Acute coronary syndrome (ACS) is one of the main manifestations of coronary artery disease, with a higher prevalence and worst prognosis. Oxidative stress is important in atherosclerosis and ACS, and paraoxonase 1 (PON1) is directly related to reducing the effects of oxidative stress on lipoproteins. The present study evaluated the prognostic value of PON1 activity in patients with non-ST-segment elevation ACS [non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA)], included in the ERICO study. Methods PON1 paraoxonase activity was determined in serum samples from 485 patients collected on admission. The prognostic value in the follow-up of up to 5 years was evaluated according to cutoff points established by tertiles. Kaplan-Meier curves and Cox regression were used for the analysis of all-cause mortality and cardiovascular mortality. Results The sample consisted mainly of elderly patients with a high frequency of cardiovascular risk factors. At follow-up of up to 5 years, there were 126 deaths from all causes (80 deaths from CVD). The lowest tertile of PON1 paraoxonase activity was associated with a higher risk of death in patients with NSTEMI, but not in patients with UA. Conclusion PON1 paraoxonase activity has potential prognostic value in patients with NSTEMI. (AU)

• Processo FAPESP: 12/14804-1 - Avaliação dos fatores prognósticos associados à síndrome coronariana aguda no momento da admissão hospitalar e após 30 dias do evento no estudo "Estratégia de registro de insuficiência coronariana" (ERICO)
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Regular