| Texto completo | |
| Autor(es): |
Alavarse, Alex Carvalho
;
Frachini, Emilli Caroline Garcia
;
da Silva, Rafael Leonardo Cruz Gomes
;
Lima, Vitoria Hashimoto
;
Shavandi, Amin
;
Petri, Denise Freitas Siqueira
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | International Journal of Biological Macromolecules; v. 202, p. 39-pg., 2022-01-25. |
| Resumo | |
Polysaccharides and proteins are important macromolecules for developing hydrogels devoted to biomedical applications. Chemical hydrogels offer chemical, mechanical, and dimensional stability than physical hydrogels due to the chemical bonds among the chains mediated by crosslinkers. There are many crosslinkers to synthesize polysaccharides and proteins based on hydrogels. In this review, we revisited the crosslinking reaction mechanisms between synthetic or natural crosslinkers and polysaccharides or proteins. The selected synthetic cross linkers were glutaraldehyde, carbodiimide, boric acid, sodium trimetaphosphate, N,N'-methylene bisacrylamide, and polycarboxylic acid, whereas the selected natural crosslinkers included transglutaminase, tyrosinase, horseradish peroxidase, laccase, sortase A, genipin, vanillin, tannic acid, and phytic acid. No less important are the reactions involving click chemistry and the macromolecular crosslinkers for polysaccharides and proteins. Literature examples of polysaccharides or proteins crosslinked by the different strategies were presented along with the corresponding highlights. The general mechanism involved in chemical crosslinking mediated by gamma and UV radiation was discussed, with particular attention to materials commonly used in digital light processing. The evaluation of crosslinking efficiency by gravimetric measurements, rheology, and spectroscopic techniques was presented. Finally, we presented the challenges and opportunities to create safe chemical hydrogels for biomedical applications. (AU) | |
| Processo FAPESP: | 20/03248-7 - Estudo da liberação de cafeína inserida em arcabouços magnéticos de xantana sob estímulo magnético |
| Beneficiário: | Vitoria Hashimoto Lima |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 20/01907-3 - Determinação das propriedades mecânicas de arcabouços magnéticos a base de polissacarídeos |
| Beneficiário: | Alex Carvalho Alavarse |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/22671-0 - Conjugados de peptídeos e polissacarídeos como materiais antimicrobianos para impressão 3D |
| Beneficiário: | Denise Freitas Siqueira Petri |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/05632-9 - Nanotopografia e propriedades nanomecânicas de scaffolds de quitosana nanoestruturados e de células aderidas sobre os mesmos |
| Beneficiário: | Rafael Leonardo Cruz Gomes da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/13492-2 - Arcabouços sintéticos e naturais aplicados à medicina regenerativa |
| Beneficiário: | Luiz Henrique Catalani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |