| Texto completo | |
| Autor(es): |
Yamada, Amanda Yaeko
;
de Souza, Andreia Rodrigues
;
de Castro Lima, Marisa de Jesus
;
Reis, Alex Domingos
;
Campos, Karoline Rodrigues
;
de Jesus Bertani, Amanda Maria
;
Tadeu de Araujo, Leonardo Jose
;
Sacchi, Claudio Tavares
;
Tiba-Casas, Monique Ribeiro
;
Camargo, Carlos Henrique
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Current Microbiology; v. 79, n. 9, p. 5-pg., 2022-09-01. |
| Resumo | |
Emergence of resistance to classical antimicrobial agents is a public health issue, especially in countries with high antimicrobial consumption rates. Carbapenems have been employed as first-choice option for empirical treatment complicated infections. However, in the last decades, frequency of carbapenemase-producing Gram-negative bacteria has rising, demanding the use of alternative antimicrobial agents. By sequencing the entire genomes with short and long reads technologies, we report the isolation and genomic characterization of a carbapenem-resistant Pseudomonas clinical isolate. The identification based on average nucleotide identity indicates a putative new species into the Pseudomonas putida Group, which carries both the bla(BKC-1) and bla(VIM-2) carbapenemase genes. The bla(BKC-1) was found to be on a transferable IncQ plasmid backbone, whereas bla(VIM-2) was found in a new integron, In2126 (intl1 increment -bla(VIM-2)-aacA7-bla(VIM-2) increment -aacA27-3'CS), described in this study. Our findings indicate that co-occurrence of classes A and B carbapenemase enzymes underscores the evolving emergence of more complex antimicrobial resistance in opportunistic pathogens. (AU) | |
| Processo FAPESP: | 17/50333-7 - Plano de desenvolvimento institucional em pesquisa do Instituto Adolfo Lutz (PDIp) |
| Beneficiário: | Carlos Henrique Camargo |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa |
| Processo FAPESP: | 18/21193-5 - EMU concedido no processo 2017/50333-7: sequenciador genético de DNA |
| Beneficiário: | Carlos Henrique Camargo |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 18/21192-9 - EMU concedido no processo 2017/50333-7: MALDI-TOF |
| Beneficiário: | Carlos Henrique Camargo |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |