Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis

Autor(es)

Gunasekera, Brandon ; Davies, Cathy ; Blest-Hopley, Grace ; Veronese, Mattia ; Ramsey, Nick F. ; Bossong, Matthijs G. ; Radua, Joaquim ; Bhattacharyya, Sagnik ; CBE Consortium

• Tipo de documento: Artigo Científico
• Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 140, p. 22-pg., 2022-08-02.

Resumo

The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neummodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These metaanalytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neummodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression. (AU)

• Processo FAPESP: 20/12110-9 - Canabidiol (CBD) em pacientes com sintomas leves a moderados do Coronavirus 2019: um ensaio clínico randomizado, duplo-cego, controlado por placebo
• Beneficiário: José Alexandre de Souza Crippa
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas
• Processo FAPESP: 20/12066-0 - A sobrecarga emocional das equipes de saúde do SUS envolvidas no atendimento aos pacientes portadores do COVID-19: avaliação da eficácia de medidas profiláticas, incluindo o uso de canabidiol
• Beneficiário: Antonio Waldo Zuardi
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas