| Texto completo | |
| Autor(es): Mostrar menos - |
Wu, Ming-Kung
;
Satogami, Kazumi
;
Liang, Chih-Sung
;
Stubbs, Brendon
;
Carvalho, Andre F.
;
Brunoni, Andre R.
;
Su, Kuan-Pin
;
Tu, Yu-Kang
;
Wu, Yi-Cheng
;
Chen, Tien-Yu
;
Li, Dian-Jeng
;
Lin, Pao-Yen
;
Hsu, Chih-Wei
;
Chen, Yen-Wen
;
Suen, Mein-Woei
;
Zeng, Bing-Yan
;
Takahashi, Shun
;
Tseng, Ping-Tao
;
Li, Cheng-Ta
Número total de Autores: 19
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| Tipo de documento: | Artigo Científico |
| Fonte: | PSYCHIATRY AND CLINICAL NEUROSCIENCES; v. 76, n. 12, p. 11-pg., 2022-10-08. |
| Resumo | |
Aim: In recent decades, the prevalence of amphetamine and methamphetamine use disorders has at least doubled in some regions/countries, with accompanying high risks of drug overdose-associated mortality. Noninvasive brain stimulation (NIBS) methods may be effective treatments. However, the comparative efficacy of the NIBS protocol for amphetamine/methamphetamine use disorder (AUD/MUD) remains unknown to date. The aim of this network meta-analysis (NMA) was to compare the efficacy and acceptability of various NIBS methods/protocols for AUD/MUD management. Methods: A frequentist model-based NMA was conducted. We included randomized controlled trials (RCTs) that investigated the efficacy of NIBS and guideline-recommended pharmacologic treatments to reduce craving severity in patients with either AUD or MUD. Results: Twenty-two RCTs including 1888 participants met the eligibility criteria. Compared with the sham/placebo group (study = 19, subjects = 891), a combination of intermittent theta burst stimulation over the left dorsolateral prefrontal cortex (DLPFC) and continuous TBS over the left ventromedial prefrontal cortex (study = 1, subjects = 19) was associated with the largest decreases in craving severity [standardized mean difference (SMD) = -1.50; 95% confidence intervals (95%CIs) = -2.70 to -0.31]. High-frequency repetitive transcranial magnetic stimulation over the left DLPFC was associated with the largest improvements in depression and quality of sleep (study = 3, subjects = 86) (SMD = -2.48; 95%CIs = -3.25 to -1.71 and SMD = -2.43; 95%CIs = -3.38 to -1.48, respectively). The drop-out rate of most investigated treatments did not significantly differ between groups. Conclusion: The combined TBS protocol over the prefrontal cortex was associated with the greatest improvement in craving severity. Since few studies were available for inclusion, additional large-scale randomized controlled trials are warranted. (AU) | |
| Processo FAPESP: | 19/06009-6 - Terapias de neuromodulação não-implantáveis: uma perspectiva para o cérebro deprimido |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/10861-7 - Avaliação multimodal dos efeitos da estimulação transcraniana por corrente contínua e estimulação theta-burst no funcionamento do córtex pré-frontal: um estudo Fase-I bilateral, placebo-controlado, fatorial |
| Beneficiário: | Andre Russowsky Brunoni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |