Polymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitis

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Silva, Arles Naisa Amaral ; Nicchio, Ingra Gagno ; da Silva, Barbara Roque ; Martelli, Mauricio Gandini Giani ; Hidalgo, Marco A. Rimachi ; Nepomuceno, Rafael ; Theodoro, Leticia H. ; Cirelli, Joni A. ; Orrico, Silvana R. P. ; Cirelli, Thamiris ; Barros, Silvana P. ; Scarel-Caminaga, Raquel M.

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 143, p. 12-pg., 2022-09-01.

Resumo

Objectives: This study aimed to investigate polymorphisms in genes considered molecular biomarkers of type 2 diabetes mellitus (T2DM) to assess whether they are associated with periodontitis, and relating them to the periodontal status, glycemic and lipid profile of the subjects. Design: We investigated individuals who underwent complete periodontal examination and biochemical evalu-ation. We categorized them into three groups: (i) periodontitis with T2DM (Periodontitis+T2DM group, n = 206); (ii) periodontitis without T2DM (Periodontitis group, n = 346); and (iii) healthy individuals without Periodontitis or T2DM (Healthy group, n = 345). We investigated three single nucleotide polymorphisms (SNPs) for AGER, RBMS1 and VEGFA genes. We applied multivariate logistic and multiple linear regression models for all groups and stratified the subjects by sex and smoking habits.Results: Compared with RBMS1-rs7593730-CC+CT genotype carriers, RBMS1-rs7593730-TT carriers were more susceptible to periodontitis [odds ratio (OR) = 2.29; 95% confidence interval (CI) = 1.04-5.01; P-value = 0.033]. Among AGER-rs184003-CC carriers, never smokers had reduced risks of periodontitis and Periodontitis+T2DM than ever smokers. For either RBMS1-rs7593730-CC or VEGFA-rs9472138-CC carriers, never smokers had less susceptibility to develop periodontitis than ever smokers. Compared with AGER-rs184003-CC carriers, AGER- rs184003-AA carriers presented fewer remaining teeth. VEGFA-rs9472138-TT carriers showed a lower per-centage of sites with characteristics of active periodontal disease (bleeding on pocket probing and interproximal clinical attachment level) compared with VEGFA-rs9472138-CC carriers.Conclusions: In the studied population, AGER rs184003, RBMS1 rs7593730, and VEGFA rs9472138, which are considered genetic markers for T2DM, were associated with periodontitis without T2DM or periodontitis together with T2DM. (AU)

• Processo FAPESP: 16/18313-3 - Investigação da susceptibilidade de variações genéticas a Periodontite Crônica por OpenArray®: Bioestatística, Bioinformática e Análise Funcional
• Beneficiário: Rafael Nepomuceno Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 16/08070-6 - Investigação da suscetibilidade genética à periodontite crônica associada ao Diabetes mellitus tipo 2
• Beneficiário: Thamiris Cirelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 14/13295-1 - Investigação da associação de variações genéticas na suscetibilidade à doença periodontal crônica por meio de OpenArray®
• Beneficiário: Rafael Nepomuceno Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado