| Texto completo | |
| Autor(es): |
Moraes-Ferreira, Renilson
;
Brandao-Rangel, Maysa Alves Rodrigues
;
Gibson-Alves, Thiago Goncalves
;
Silva-Reis, Anamei
;
Souza-Palmeira, Victor Hugo
;
Aquino-Santos, Helida Cristina
;
Frison, Claudio Ricardo
;
Oliveira, Luis Vicente Franco
;
Albertini, Regiane
;
Vieira, Rodolfo P.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; v. 2022, p. 13-pg., 2022-10-20. |
| Resumo | |
Several benefits of aerobic training for asthmatic patients have been demonstrated. However, its effects on systemic inflammation and on airway remodeling mediators and lung mechanics are unknown. This prospective study included 21 intermittent and mild asthma patients, and as primary outcomes, the evaluation of pro- and anti-inflammatory and pro- and antifibrotic mediators in exhaled breath condensate (EBC) and blood were performed, beyond the cell counting in blood and in induced sputum. Aerobic training was performed for 3 months, 3 times per week. Aerobic training increased the levels of anti-inflammatory cytokines and of antifibrotic mediators in the breath condensate: IL-1ra (p=0.0488), IL-10 (p=0.0048), relaxin-3 (p=0.0019), and klotho (p < 0.0043), respectively. Similarly, in plasma, increased levels of IL-1ra (p=0.0147), IL-10 (p < 0.0001), relaxin-3 (p=0.004), and klotho (p=0.0023) were found. On contrary, reduced levels of proinflammatory cytokines in the breath condensate, IL-1 beta (p=0.0008), IL-4 (p=0.0481), IL-5 (p < 0.0001), IL-6 (p=0.0032), IL-13 (p=0.0013), and TNF-alpha (p=0.0001) and profibrotic markers VEGF (p=0.0017) and TSLP (p=0.0056) were found. Similarly, in plasma, aerobic training significantly reduced the levels of proinflammatory cytokines IL-1 beta (p=0.0008), IL-4 (p=0.0104), IL-5 (p=0.0001), IL-6 (p=0.006), IL-13 (p=0.0341), and TNF-alpha (p=0.0003) and of profibrotic markers VEGF (p=0.0009) and TSLP (p < 0.0076). Fractional exhaled nitric oxide (FeNO) was reduced after the intervention (p=0.0313). Regarding inflammatory cells in sputum, there was a reduction in total cells (p=0.008), eosinophils (p=0.009), and macrophages (p=0.020), as well as of blood eosinophils (p=0.0203) and lymphocytes (p=0.0198). Aerobic training positively modulates chronic airway inflammation and remodeling mediators, beyond to improve systemic inflammation in intermittent and mild asthmatic patients. (AU) | |
| Processo FAPESP: | 20/03994-0 - Proteínas pro e anti-fibróticas e asma: existe uma correlação entre seus níveis com a inflamação e resistência das vias aéreas? |
| Beneficiário: | Victor Hugo Souza Palmeira |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 19/11008-9 - O papel do treinamento físico nas respostas pró e anti-fibróticas pulmonares de indivíduos asmáticos |
| Beneficiário: | Renilson Moraes Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos |
| Beneficiário: | Rodolfo de Paula Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/11244-4 - Efeitos do treinamento físico combinado sobre a mecânica e função pulmonar e sobre a resposta imune pulmonar e sistêmica de mulheres obesas |
| Beneficiário: | Anamei Silva Reis |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/05739-0 - Papel das cininas nos efeitos anti-inflamatórios do treinamento aeróbio em modelo experimental de Asma |
| Beneficiário: | Maysa Alves Rodrigues Brandão Rangel |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |