Acai pulp improves cognition and insulin sensitivity in obese mice

Autor(es)

Medina dos Santos, Nathalia ; Batista, angela Giovana ; Mendonca, Monique Culturato Padilha ; Angolini, Celio Fernando Figueiredo ; Grimaldi, Renato ; Pastore, Glaucia Maria ; Sartori, Cesar Renato ; da Cruz-Hoefling, Maria Alice ; Marostica Jr, Mario Roberto

• Tipo de documento: Artigo Científico
• Fonte: NUTRITIONAL NEUROSCIENCE; v. N/A, p. 11-pg., 2023-01-06.

Resumo

ScopeObesity and insulin resistance constitute risk factors for the development of tauopathies and other neurodegenerative diseases. (Poly)phenol compounds are under study for its role in protecting effects against neural injuries and degeneration. Here, we investigated the effect of Amazonian acai pulp (AP) intake in the prevention of memory and cognitive impairment resulting from a high-fat diet intake in mice.Methods and resultsObesity and insulin resistance was induced with a high-fat diet and supplemented with 2% AP to investigate peripheral insulin resistance, recognition memory and tau protein stability via AKT/GSK3-beta signaling pathway. The consumption of AP for 70 days improved peripheral insulin sensitivity and phosphorylation of AKT/GSK3-beta in mice hippocampi. The animals fed high-fat diets supplemented with AP showed better performance in the novel object recognition test (NOR) in comparison to the H group. Catalase activity and reduced glutathione (GSH) values were improved in the treated mice.ConclusionsThese results suggest that the supplementation of AP can attenuate the effects of high-fat diet consumption in peripheral insulin resistance and improve cognitive behavior. (AU)

• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos
• Beneficiário: Mário Roberto Maróstica Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular