Exposure to Sodium Hypochlorite or Cigarette Smoke Induces Lung Injury and Mechanical Impairment in Wistar Rats

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Saraiva-Romanholo, Beatriz Mangueira ; de Genaro, Isabella Santos ; de Almeida, Francine Maria ; Felix, Soraia Nogueira ; Cottes Lopes, Marina Ribeiro ; Amorim, Thais Santos ; Vieira, Rodolfo Paula ; Arantes-Costa, Fernanda Magalhaes ; Martins, Milton Arruda ; Lopes Calvo Tiberio, Iolanda de Fatima ; Prado, Carla Maximo

• Tipo de documento: Artigo Científico
• Fonte: Inflammation; v. 45, n. 4, p. 20-pg., 2022-05-02.

Resumo

Pulmonary irritants, such as cigarette smoke (CS) and sodium hypochlorite (NaClO), are associated to pulmonary diseases in cleaning workers. We examined whether their association affects lung mechanics and inflammation in Wistar rats. Exposure to these irritants alone induced alterations in the lung mechanics, inflammation, and remodeling. The CS increased airway cell infiltration, acid mucus production, MMP-12 expression, and alveolar enlargement. NaClO increased the number of eosinophils and macrophages in the bronchoalveolar lavage fluid, with cells expressing IL-13, MMP-12, MMP-9, TIMP-1, and iNOS in addition to increased IL-1 beta and TNF-alpha levels. Co-exposure to both irritants increased epithelial and smooth muscle cell area, acid mucus production, and IL-13 expression in the airways, while it reduced the lung inflammation. In conclusion, the co-exposure of CS with NaClO reduced the pulmonary inflammation, but increased the acidity of mucus, which may protect lungs from more injury. A cross-resistance in people exposed to multiple lung irritants should also be considered. (AU)

• Processo FAPESP: 09/53904-9 - Efeitos do ambiente e do estilo de vida sobre a asma e a doença pulmonar obstrutiva crônica: estudos experimentais e clínicos
• Beneficiário: Milton de Arruda Martins
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/06088-0 - Efeito do tratamento com eugenol e deidrodieugenol isolados de Nectandra leucantha (Lauraceae) em modelos experimentais de doenças pulmonares agudas e crônicas.
• Beneficiário: Carla Máximo Prado
• Modalidade de apoio: Auxílio à Pesquisa - Regular