In vitro Antibacterial Potential of the Oleoresin, Leaf Crude Hydroalcoholic Extracts and Isolated Compounds of the Copaifera spp. Against Helicobacter pylori

Autor(es)

Moraes, Thais da Silva ; Lima, Lucas Kozoski ; Veneziani, Rodrigo Cassio Sola ; Ambrosio, Sergio Ricardo ; dos Santos, Raquel Alves ; da Silva, Jonas Joaquim Mangabeira ; Ribeiro, Gustavo Lima ; Bastos, Jairo Kenupp ; Martins, Carlos Henrique Gomes

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOLOGICALLY ACTIVE PRODUCTS FROM NATURE; v. 11, n. 2, p. 7-pg., 2021-03-04.

Resumo

Helicobacter pylori is often related to severe clinical manifestations of infections and may increase an individual's chance of developing stomach cancer. We are reporting the in vitro anti-H. pylori effects of several Copaifera spp. derivatives such as oleoresins, hydroalcoholic crude extracts from the leaves, and isolated compounds, by determining their Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values. It was obtained promising MIC (MBC) values, ranging from 6.25 (12.5) to 100 (400) mu g/mL, from 12.5 (25) to 100 (100) mu g/mL, and from 3.12 (3.12) to 100 (100) mu g/mL respectively, for Copaifera spp. oleoresins, leave crude hydroalcoholic extracts and isolated compounds. Therefore, all Copaifera spp. derivatives displayed promising antibacterial activities against H. pylori. (AU)

• Processo FAPESP: 11/13630-7 - Validação química e farmacológica de extratos e princípios ativos de espécies de Copaifera
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/19714-9 - Investigação preliminar anti-Helicobacter pylori de especies de Copaifera spp
• Beneficiário: Lucas Kozoski de Lima
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/25237-0 - Diterpenos do tipo caurano: atividade antibacteriana frente a bactérias anaeróbias e análise proteômica
• Beneficiário: Carlos Henrique Gomes Martins
• Modalidade de apoio: Auxílio à Pesquisa - Regular