The preventive and therapeutic effects of anthocyanins on colorectal cancer: A comprehensive review based on up-to-date experimental studies

Autor(es)

do Nascimento, Roberto de Paula ; Machado, Ana Paula da Fonseca

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 170, p. 27-pg., 2023-05-30.

Resumo

Colorectal cancer (CRC) is the second most lethal and the third most diagnosed type of cancer worldwide. More than 75% of CRC cases are sporadic and lifestyle-related. Risk factors include diet, physical inactivity, genetics, smoking, alcohol, changes in the intestinal microbiota, and inflammation-related diseases such as obesity, diabetes, and inflammatory bowel diseases. The limits of conventional treatments (surgery, chemotherapy, radiotherapy), as demonstrated by the side effects and resistance of many CRC patients, are making professionals search for new chemopreventive alternatives. In this context, diets rich in fruits and vegetables or plant-based products, which contain high levels of phytochemicals, have been postulated as complementary therapeutic options. Anthocyanins, phenolic pigments responsible for the vivid colors of most red, purple, and blue fruits and vegetables, have been shown protective effects on CRC. Berries, grapes, Brazilian fruits, and vegetables such as black rice and purple sweet potato are examples of products rich in anthocyanins, which have been able to reduce cancer development by modulating signaling pathways associated with CRC. Therefore, this review has as main objective to present and discuss the potential preventive and therapeutic effects of anthocyanins present in fruits and vegetables, in plant extracts, or in their pure form on CRC, taking into account up-to-date experimental studies (2017-2023). Additionally, a highlight is given towards the mechanisms of action of anthocyanins on CRC. (AU)

• Processo FAPESP: 19/03228-9 - Efeitos do consumo preventivo do pó liofilizado da casca da jabuticaba em camundongos BALB/c com Câncer Colorretal induzido por azoximetano/dextran sulfato de sódio
• Beneficiário: Roberto de Paula do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/10485-0 - Pó liofilizado da casca da jabuticaba na prevenção do câncer colorretal: mecanismos em camundongos 'wild type' e geneticamente modificados
• Beneficiário: Roberto de Paula do Nascimento
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado