Busca avançada
Ano de início
Entree


Sirtuins: Key pieces in the host response to pathogens' puzzle

Texto completo
Autor(es):
Silva, Rafael de Freitas e ; Bassi, Gabriela ; Camara, Niels Olsen Saraiva ; Moretti, Nilmar Silvio
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Molecular Immunology; v. 160, p. 11-pg., 2023-07-10.
Resumo

Global warming is changing the distribution of different pathogens around the globe, and humans are more susceptible to new or re-emerging infections. The human response to microbes is complex and involves different mechanisms of the immune system. Regulation of gene expression of immunity genes and of metabolism of immune cells are essential in this process. Both mechanisms could be regulated by protein lysine acetylation that will control chromatin structure affecting gene expression or key enzyme activity involved in cellular processes. Protein acetylation is crucial for the immunity and involves two families of enzymes: lysine acetyltransferases (KATs), which will promote protein acetylation, and lysine deacetylases (KDACs) that will reduce this modification. Lysine deacetylases are divided into Zinc-dependent or HDACs and NAD+ -dependent, or Sirtuins. These enzymes are in the nucleus, cytosol, and mitochondria of mammalian cells affecting different cellular pathways, such as metabolism, gene expression, DNA repair, cell proliferation, and apoptosis, opening the opportunity to explore these proteins as drug targets in different diseases, including cancer and neurodegenerative illness. Although widely explored in chronic diseases, very little is known about the role of Sirtuins during host response against microbes' infection. In this review we aim to explore the most recent literature evidencing a role for these enzymes during host responses to viruses, bacterial and protozoan infections, pointing out how these proteins can be manipulated by these pathogens to progress in the infection. Moreover, we will uncover the potential of host KDACs as therapeutic targets to prevent infections by activating effector immune functions. (AU)

Processo FAPESP: 18/09948-0 - Estudo da acetilação proteica em Leishmania
Beneficiário:Nilmar Silvio Moretti
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 20/07870-4 - Mecanismos de adaptação de tripanossomatídeos ao hospedeiro através de controle da transcrição, síntese proteica e secreção de vesículas extracelulares
Beneficiário:Ana Claudia Trocoli Torrecilhas
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 22/03075-0 - Desvendando os mecanismos regulatórios envolvidos na relação parasito hospedeiro da Leishmania: foco nas alterações pós-transcricionais e pós-traducionais
Beneficiário:Nilmar Silvio Moretti
Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial