| Texto completo | |
| Autor(es): |
de Almeida, Herllan V.
;
Catori, Daniele M.
;
da Silva, Laura C. E.
;
de Oliveira, Marcelo G.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MACROMOLECULAR SYMPOSIA; v. 406, n. 1, p. 6-pg., 2022-12-01. |
| Resumo | |
S-nitrosothiols (RSNOs) are nitric oxide (NO) donor molecules with potential biomedical applications since they mimic NO biological functions, such as vasodilation and inflammatory process regulation. In this work, chitosan (CS), a natural biopolymer widely used as a biomaterial, is functionalized with thioglycolic acid (TGA) or mercaptosuccinic acid (MSA) in reactions mediated by a carbodiimide, yielding CS with thiol contents of 88 mu mol g(-1) (CS-TGA) and 126 mu mol g(-1) (CS-MSA). The subsequent S-nitrosation of CS-TGA and CS-MSA generates the corresponding S-nitroso derivatives, CS-TGA(SNO) and CS-MSA(SNO). The UV-Vis spectral changes associated with the S-NO bond cleavage of CS-TGA(SNO) and CS-MSA(SNO), monitored in solution over 18 days of storage in a common refrigerator, reveal that these S-nitroso CS derivatives display enhanced thermal stability in the dark, with half-life values of 36.1 for CS-TGA(SNO) and 16.1 days for CS-MSA(SNO). Conversely, CS-TGA(SNO) and CS-MSA(SNO) can release NO photochemically on-demand under visible light irradiation in a first-order process triggered by photon absorption that leads to a half-life of 33 min for both S-nitroso CS. These results show that CS-TGA(SNO) and CS-MSA(SNO) may emerge as new CS-based biomaterials for providing light-triggered local NO release in biomedical applications. (AU) | |
| Processo FAPESP: | 18/14142-5 - Hidrogéis híbridos para liberação localizada e prolongada de óxido nítrico |
| Beneficiário: | Laura Caetano Escobar da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 16/02414-5 - Biomateriais absorvíveis e tópicos para a liberação localizada de óxido nítrico |
| Beneficiário: | Marcelo Ganzarolli de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |