Cobalt(III)-py₂en systems as potential carriers of β-ketoester-based ligands

Autor(es)

Palmeira-Mello, Marcos, V ; Caballero, Ana B. ; Herrera-Ramirez, Piedad ; Costa, Analu R. ; Santana, Savyo S. ; Guedes, Guilherme P. ; Caubet, Amparo ; Batista, Alzir Azevedo ; Gamez, Patrick ; Lanznaster, Mauricio

• Tipo de documento: Artigo Científico
• Fonte: Journal of Inorganic Biochemistry; v. 248, p. 11-pg., 2023-11-01.

Resumo

Two cobalt(III) complexes containing different beta-ketoesters, namely [Co-III(L1)(py(2)en)](ClO4)(2)center dot H2O (1) and [Co-III(L2)(py(2)en)](ClO4)(2) (2) (py(2)en = N,N '-bis(pyridin-2-ylmethyl)ethylenediamine; L1(-) = methylacetoacetate; L2(-) = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of beta-ketoester and py(2)en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via X-ray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37 degrees C results in the release of the beta-ketoester ligands upon Co(III)/Co(II) reduction. (AU)

• Processo FAPESP: 21/01787-0 - Estudo in vitro e in vivo de complexos fosfínicos de Ru(II) com atividades anticancerígenas
• Beneficiário: Marcos Vinícius Palmeira de Mello
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado