Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction

Autor(es)

Gotardo, Erica Martins Ferreira ; de Morais, Thaina Rodrigues ; Ferreira, Ana Paula Timoteo ; Caria, Cintia Rabelo e Paiva ; Ribeiro, Marcelo Lima ; Gambero, Alessandra

• Tipo de documento: Artigo Científico
• Fonte: CURRENT DRUG TARGETS; v. 24, n. 8, p. 9-pg., 2023-01-01.

Resumo

Introduction Several studies demonstrated that deferoxamine, an iron chelator, can improve inflammatory alterations in adipose tissue induced by obesity. Obesity alterations in adipose tissue are also associated with tissue remodeling, and deferoxamine has anti-fibrosis action previously described in sites like the skin and liver. Methods In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during obesity induced by diet in mice. in vitro approaches with fibroblasts and macrophages were also carried out to elucidate deferoxamine activity. Results Our results demonstrated that in addition to exerting anti-inflammatory effects, reducing the cytokine production in adipose tissue of obese mice and by human monocyte differentiated in macrophage in vitro, deferoxamine can alter metalloproteinases expression and extracellular matrix production in vivo and in vitro. Conclusion Deferoxamine could be an alternative to control fibro-inflammation in obese adipose tissue, contributing to the metabolic improvements previously described. (AU)

• Processo FAPESP: 14/04986-0 - Avaliação do fenótipo de macrófagos na capacidade de produção de hepcidina e incorporação de ferro: possível efeito local no tecido adiposo.
• Beneficiário: Ana Paula Timóteo Ferreira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/03665-7 - "ações dos quelantes de ferro sobre o tecido adiposo e músculo esquelético de camundongos obesos e in vitro em modelo de 3T3-L1 e C2C12."
• Beneficiário: Thainá Rodrigues de Morais
• Modalidade de apoio: Bolsas no Brasil - Mestrado