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Antimicrobial resistance genotypes and phenotypes of Campylobacter coli isolated from different sources over a 16-year period in Brazil

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Autor(es):
Gomes, Carolina Nogueira ; Campioni, Fabio ; Barker, Dillon Oliver Reese ; Che, Emily Victoria ; Duque, Sheila da Silva ; Taboada, Eduardo Napoleon ; Falcao, Juliana Pfrimer
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE; v. 33, p. 5-pg., 2023-06-01.
Resumo

Objectives: This study aimed to identify antimicrobial resistance genotypes in 63 Campylobacter coli strains isolated from humans (12), animals (21), the environment (20), and food (10) in Brazil using whole genome sequencing (WGS) tools, comparing them with results obtained by antimicrobial susceptibility testing (AST) against some important antimicrobials in clinical use.Methods: Phenotypic resistance profiles were determined by minimal inhibitory concentrations and the disk diffusion technique. The prediction of the resistance genes was performed using ABRicate v.0.8 and the Resistance Gene Identifier software of the CARD. Results: The percentage of C. coli strains phenotypically resistant to antimicrobials were: ampicillin, 44.4%; doxycycline, 20.6%; tetracycline, 20.6%; ciprofloxacin, 12.7%; nalidixic acid, 12.7%; streptomycin, 6.3%; erythromycin, 4.8%; and gentamicin, 1.6%. The genes bla OXA-605 / bla OXA-61, tet (O), cme B, aadE -Cc, aph (3 ') - IIIa, sat 4 and aad 9 were detected in 54%, 22.2%, 9.5%,6.3%, 1.6%, 1.6%, and 1.6% strains, respectively. Mutations T86I in the QRDR region of gyr A were detected in 8 (12.7%) strains. The agreement between AST and WGS was 100%, 92.9%, 82.4%, and 80% for quinolones, tetracycline, & beta;-lactam, and aminoglycoside classes, respectively.Conclusions: The rates of C. coli strains resistant to & beta;- lactams and quinolones may represent a public health concern. The partial agreement between AST and WGS shows that improvement in antibiotic resistance databases may be required to minimize this discrepancy observed in some antimicrobial classes and to become an acceptable tool to both clinical microbiologists and regulatory agencies. & COPY; 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) (AU)

Processo FAPESP: 22/07013-0 - Análises do genoma, transcriptoma, construção de mutantes e caracterização fenotípica de linhagens de Campylobacter coli isoladas de diversas fontes durante 25 anos no Brasil
Beneficiário:Juliana Pfrimer Falcão
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/26043-1 - Sequenciamento do genoma completo e análise genômica comparativa de linhagens de Campylobacter coli isoladas de diversas fontes durante 16 anos no Brasil
Beneficiário:Carolina Nogueira Gomes
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 16/24716-3 - Sequenciamento do genoma, transcriptoma e análise fenotípica de linhagens de Campylobacter coli isoladas de diversas fontes no Brasil
Beneficiário:Juliana Pfrimer Falcão
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/19338-8 - Genômica, transcriptômica e caracterização fenotipica de linhagens de Campylobacter jejuni isoladas de diversas fontes durante 20 anos no Brasil
Beneficiário:Juliana Pfrimer Falcão
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/23408-0 - Análise fenotípica, sequenciamento do genoma e transcriptoma de linhagens de Campylobacter coli isoladas de diversas fontes durante 16 anos no Brasil
Beneficiário:Carolina Nogueira Gomes
Modalidade de apoio: Bolsas no Brasil - Doutorado