| Texto completo | |
| Autor(es): |
Pires, Claudia T. A.
;
Scodro, Regiane B. L.
;
Cortez, Diogenes A. G.
;
Brenzan, Mislaine A.
;
Siqueira, Vera L. D.
;
Caleffi-Ferracioli, Katiany R.
;
Vieira, Lucas C. C.
;
Monteiro, Julia L.
;
Correa, Arlene G.
;
Cardoso, Rosilene F.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Future Medicinal Chemistry; v. 12, n. 17, p. 14-pg., 2020-08-21. |
| Resumo | |
Aim:Eight coumarin derivatives (1a-h) obtained from natural (-)-mammea A/BB (1) and 13 synthetic coumarins (2-14) had their cytotoxicity and biological activity evaluated againstMycobacterium tuberculosisH(37)Rv reference strain and multidrug-resistant clinical isolates.Materials & methods:Anti-M. tuberculosisactivity was evaluated by resazurin microtiter assay plate, and the cytotoxicity of natural and synthetic products using J774A.1 macrophages by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.Results:Compounds1g,5,6,12and14were more active againstM. tuberculosisH(37)Rv and multidrug-resistant clinical isolates with minimum inhibitory concentration values ranging from 15.6 to 62.5 mu g/ml.Conclusion:These results demonstrate that the coumarin derivatives were active against multidrug-resistant clinical isolates, becoming potential candidates to be used in the treatment of resistant tuberculosis. (AU) | |
| Processo FAPESP: | 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock |
| Beneficiário: | Arlene Gonçalves Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Centros de Pesquisa Aplicada |
| Processo FAPESP: | 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos |
| Beneficiário: | Glaucius Oliva |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 15/17141-1 - Desenvolvimento e Estudos Mecanísticos de Novas Metodologias Sintéticas para Síntese de Compostos Bioativos |
| Beneficiário: | Ricardo Samuel Schwab |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |