Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach

Autor(es)

Silva, Simone S. ; Rodrigues, Luisa C. ; Fernandes, Emanuel M. ; da Costa, Diana Soares ; Villalva, Denise G. ; Loh, Watson ; Reis, Rui L.

• Tipo de documento: Artigo Científico
• Fonte: MARINE DRUGS; v. 21, n. 7, p. 15-pg., 2023-07-01.

Resumo

Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 & mu;m, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 & PLUSMN; 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 & PLUSMN; 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway. (AU)

• Processo FAPESP: 19/12665-3 - Biomateriais engenheirados baseados em óleo de coco e polímeros naturais: novas rotas para desenvolvimento de produtos biomédicos com alto valor agregado
• Beneficiário: Denise Gradella Villalva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/08045-7 - Biomateriais engenheirados baseados em óleo de coco e polímeros naturais: novas rotas para desenvolvimento de produtos biomédicos com alto valor agregado
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Regular