Busca avançada
Ano de início
Entree


Maternal plasma transforming growth factor-b1 (TGF-b1) and newborn size: the Araraquara Cohort Study

Texto completo
Autor(es):
Mostrar menos -
Dejani, Naiara Naiana ; Nicoletti, Carolina F. ; Argentato, Perla Pizzi ; Pereira, Ludmilla da Silva ; Saraiva, Amanda Correia ; de Assis, Leticia Montanha ; Nakandakare, Patricia Yury ; Batista, Livia Patricia Rodrigues ; Teles, Laisla de Franca da Silva ; Leitao, Maria Paula ; Luzia, Liania Alves ; de Medeiros, Alexandra Ivo ; Rondo, Patricia Helen
Número total de Autores: 13
Tipo de documento: Artigo Científico
Fonte: Jornal de Pediatria; v. 99, n. 3, p. 5-pg., 2023-05-01.
Resumo

Objective: To investigate associations of maternal and cord blood cytokine patterns with new-born size and body composition. Methods: This cross-sectional study involved 70 pregnant women and their healthy newborns selected from the "Araraquara Cohort Study". Newborn anthropometric measurements were recorded at birth. Body composition was evaluated by air displacement plethysmography. Mater -nal blood samples were collected from pregnant women between 30 and 36 weeks of gestation, and umbilical cord blood samples were collected immediately after placenta discharge. The con-centrations of the cytokines were determined in plasma by ELISA. Multiple linear regression mod -els were used to assess associations between maternal and cord blood cytokine concentrations and newborn anthropometry and body composition measurements. Results: Maternal plasma TGF-fi1 concentration was inversely associated with newborn weight (fi =-43.0; p = 0.012), length (fi =-0.16, p = 0.028), head circumference (fi =-0.13, p = 0.004), ponderal index (fi =-0.32, p = 0.011) and fat-free mass (fi =-0.05, p = 0.005). However, the asso-ciation persisted just for head circumference (fi =-0.26; p = 0.030) and ponderal index (fi = - 0.28; p = 0.028), after adjusting for pre-gestational BMI, gestational weight gain, gestational age, hours after delivery, newborn sex, smoking and alcohol consumption. Conclusions: Maternal plasma TGF-b1 concentration may be involved in the regulation of new-born size, mainly head circumference and ponderal index. Further cohort studies are necessary to investigate the role of TGF-b1 in different trimesters of pregnancy and its effect during the early stages of fetal development. (c) 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/). (AU)

Processo FAPESP: 15/03333-6 - Relação entre adiposidade materna e adiposidade do concepto nos períodos fetal, neonatal e no primeiro ano de vida: estudo prospectivo de base populacional
Beneficiário:Patricia Helen de Carvalho Rondó
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/17824-0 - Perfil da metilação do DNA do binômio mãe-concepto no contexto da Obesidade materna e adiposidade fetal e neonatal
Beneficiário:Perla Pizzi Argentato
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 18/19638-9 - Reprogramação metabólica de células dendríticas após eferocitose de células apoptóticas
Beneficiário:Letícia de Aquino Penteado
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 17/07143-2 - Uma abordagem imunológica da relação entre adiposidade materna e do concepto nos períodos fetal, neonatal e no primeiro ano de vida
Beneficiário:Naiara Naiana Dejani
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado