| Texto completo | |
| Autor(es): Mostrar menos - |
Zimerman, Jeanini
;
Nino, Oscar M. S.
;
da Costa, Charles S.
;
Zanol, Jordana F.
;
Comerio, Milena
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de Souza, Leticia N. da Gama
;
Miranda-Alves, Leandro
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Miranda, Rosiane A.
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Lisboa, Patricia C.
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Camilo, Tays A.
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Rorato, Rodrigo
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Alves, Guilherme Andrade
;
Frazao, Renata
;
Zomer, Helena D.
;
Freitas-Lima, Leandro C.
;
Graceli, Jones B.
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | REPRODUCTIVE TOXICOLOGY; v. 119, p. 13-pg., 2023-05-29. |
| Resumo | |
We previously reported that female rats placed on a diet containing refined carbohydrates (HCD) resulted in obesity and reproductive abnormalities, such as high serum LH concentration and abnormal ovarian function. However, the impacts at the hypothalamic-pituitary (HP) function, specifically regarding pathways linked to reproductive axis modulation are unknown. In this study, we assessed whether subacute feeding with HCD re-sults in abnormal reproductive control in the HP axis. Female rats were fed with HCD for 15 days and repro-ductive HP axis morphophysiology was assessed. HCD reduced hypothalamic mRNA expression (Kiss1, Lepr, and Amhr2) and increased pituitary LH & beta;+ cells. These changes likely contribute to the increase in serum LH con-centration observed in HCD. Blunted estrogen negative feedback was observed in HCD, with increased kisspeptin protein expression in the arcuate nucleus of the hypothalamus (ARH), lower LH & beta;+ cells and LH concentration in ovariectomized (OVX)+HCD rats. Thus, these data suggest that HCD feeding led to female abnormal repro-ductive control of HP axis. (AU) | |
| Processo FAPESP: | 16/17968-6 - Circuitaria e fenótipos neuronais hipotalâmicos envolvidos no acoplamento da atividade do eixo hipotálamo-hipófise-adrenal às alterações da homeostase energética |
| Beneficiário: | Rodrigo César Rorato |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/21707-1 - Influência da privação alimentar na excitabilidade de neurônios que expressam o gene Kiss1 |
| Beneficiário: | Renata Frazão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |