| Texto completo | |
| Autor(es): Mostrar menos - |
Correia, Banny Silva Barbosa
;
Pontes, Joao Guilherme de Moraes
;
Nani, Joao Victor Silva
;
Villalta, Fabian
;
Mor, Natalia Cristina
;
Bordini, Daniela
;
Brunoni, Decio
;
Brentani, Helena
;
Mari, Jair Jesus
;
Hayashi, Mirian A. F.
;
Tasic, Ljubica
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS Chemical Neuroscience; v. 14, n. 6, p. 9-pg., 2023-02-21. |
| Resumo | |
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by patients displaying at least two out of the classical symptoms, such as impaired social communication, impaired interactions, and restricted repeti t i v e behavior. Early parent-mediated interventions, such as video modeling for parental training, were demonstrated to be a successf u l low-cost way to del i v e r care for children with ASD. Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been success-fully employed in several mental disorder studies. Metabolomics and lipidomics of 37 ASD patients (children, aged 3-8 years), who were divided into two groups, one control group with no parental-training intervention (N = 18) and the other in which the parents were trained by a video modeling intervention (ASD parental training, N = 19), were analyzed by proton NMR spectroscopy. Patients in the ASD parental-training group sera were seen to have increased glucose, myo-inositol, malonate, prol i n e , phenylalanine, and gangliosides in their blood ser u m , while cholesterol, choline, and lipids were decreased, compared to the control group, who received no parental-training. Taken together, we demonstrated here significant changes in serum metabolites and lipids in ASD children, previously demonstrated to show clinical positive efl'ects following a parental training intervention based on video modeling, delivered over 22 weeks. We demonstrate the value of applying metabolomics and lipidomics to identify potential biomarkers for clinical interventions follow-up in ASD. (AU) | |
| Processo FAPESP: | 19/09207-3 - Estudo do(s) mecanismo(s) molecular(es) e celular(es) em transtornos mentais |
| Beneficiário: | João Victor Silva Nani |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua |
| Beneficiário: | Fernando Barbosa Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica |
| Beneficiário: | Marco Aurelio Zezzi Arruda |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/13112-8 - Estudo dos mecanismos moleculares e celulares em transtornos mentais: estudos clínicos e modelos animais |
| Beneficiário: | Mirian Akemi Furuie Hayashi |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/01107-7 - Estudo para otimização do uso da crotamina como teranóstico na terapia de doenças humanas: câncer, síndrome metabólica e disfunções renais |
| Beneficiário: | Mirian Akemi Furuie Hayashi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |