Recent Advances in Greener Asymmetric Organocatalysis Using Bio-Based Solvents

Autor(es)

Martelli, Lorena S. R. ; Machado, Ingrid V. V. ; dos Santos, Jhonathan R. N. ; Correa, Arlene G. G.

• Tipo de documento: Artigo Científico
• Fonte: CATALYSTS; v. 13, n. 3, p. 52-pg., 2023-03-01.

Resumo

Efficient synthetic methods that avoid the extensive use of hazardous reagents and solvents, as well as harsh reaction conditions, have become paramount in the field of organic synthesis. Organocatalysis is notably one of the best tools in building chemical bonds between carbons and carbon-heteroatoms; however, most examples still employ toxic volatile organic solvents. Although a portfolio of greener solvents is now commercially available, only ethyl alcohol, ethyl acetate, 2-methyltetrahydrofuran, supercritical carbon dioxide, ethyl lactate, and diethyl carbonate have been explored with chiral organocatalysts. In this review, the application of these bio-based solvents in asymmetric organocatalytic methods reported in the last decade is discussed, highlighting the proposed mechanism pathway for the transformations. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/23761-0 - Síntese estereosseletiva de heterociclos a partir de abertura de epóxidos ou azidirinas quirais
• Beneficiário: Lorena Suelen Ribeiro Martelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado