Amitriptyline efficacy in decreasing implant-induced foreign body reaction

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Scheuermann, Karina ; Viana, Celso Tarso Rodrigues ; dos Reis, Diego Carlos ; de Lazari, Marcela Guimaraes Takahashi ; Orellano, Laura Alejandra Ariza ; Machado, Clara Tolentino ; dos Santos, Leticia Cristine Cardoso ; Ulrich, Henning ; Capettini, Luciano Santos Aggum ; Andrade, Silvia Passos ; Campos, Paula Peixoto

• Tipo de documento: Artigo Científico
• Fonte: IUBMB Life; v. N/A, p. 11-pg., 2023-04-22.

Resumo

Beyond its actions on the nervous system, amitriptyline (AM) has been shown to lower inflammatory, angiogenic, and fibrogenic markers in a few pathological conditions in human and in experimental animal models. However, its effects on foreign body reaction (FBR), a complex adverse healing process, after biomedical material implantation are not known. We have evaluated the effects of AM on the angiogenic and fibrogenic components on a model of implant-induced FBR. Sponge disks were implanted subcutaneously in C57BL/6 mice, that were treated daily with oral administration of AM (5 mg/ kg) for seven consecutive days in two protocols: treatment was started on the day of surgery and the implants were removed on the seventh day after implantation and treatment started 7 days after implantation and the implants removed 14 after implantation. None of the angiogenic (vessels, Vascular endothelial growth factor (VEGF), and interleukin-1 ss (IL-1 ss) or fibrogenic parameters (collagen, TGF-ss, and fibrous capsule) and giant cell numbers analyzed were attenuated by AM in 7-day-old implants. However, AM was able to downregulate angiogenesis and FBR in 14-day-old implants. The effects of AM described here expands its range of actions as a potential agent capable of attenuating fibroproliferative processes that may impair functionality of implantable devices. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático