Thrombosis Occurrence in COVID-19 Compared With Other Infectious Causes of ARDS: A Contemporary Cohort*

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Coy-Cangucu, Andrea ; Locachevic, Gisele A. ; Mariolano, Joao Carlos S. ; Soares, Kaio Henrique De O. ; Oliveira, Jose Diogo ; Vaz, Camila De Oliveira ; Vieira-Damiani, Gislaine ; Mazetto, Bruna ; Annichino-Bizzacchi, Joyce Maria ; De Paula, Erich V. ; Orsi, Fernanda A.

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS; v. 29, p. 10-pg., 2023-01-01.

Resumo

Thrombosis occurrence in coronavirus disease 2019 (COVID-19) has been mostly compared to historical cohorts of patients with other respiratory infections. We retrospectively evaluated the thrombotic events that occurred in a contemporary cohort of patients hospitalized between March and July 2020 for acute respiratory distress syndrome (ARDS) according to the Berlin Definition and compared those with positive and negative real-time polymerase chain reaction results for wild-type severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) using descriptive analysis. The association between COVID-19 and thrombotic risk was evaluated using logistic regression. 264 COVID-19-positive (56.8% male, 59.0 years [IQR 48.6-69.7], Padua score on admission 3.0 [2.0-3.0]) and 88 COVID-19-negative patients (58.0% male, 63.7 years [51.2-73.5], Padua score 3.0 [2.0-5.0]) were included. 10.2% of non-COVID-19 and 8.7% of COVID-19 patients presented( )>=( )1 clinically relevant thrombotic event confirmed by imaging exam. After adjustment for sex, Padua score, intensive care unit stay, thromboprophylaxis, and hospitalization length, the odds ratio for thrombosis in COVID-19 was 0.69 (95% CI, 0.30-1.64). We, therefore, conclude that infection-induced ARDS carries an inherent thrombotic risk, which was comparable between patients with COVID-19 and other respiratory infections in our contemporary cohort. (AU)

• Processo FAPESP: 16/14172-6 - Investigação de aspectos fisiopatológicos e novas abordagens terapêuticas em doenças tromboembólicas
• Beneficiário: Joyce Maria Annichino-Bizzacchi
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/12630-2 - Contribuição das redes extracelulares de neutrófilos (NETs) e da ativação plaquetária para a imunotrombose na COVID-19 e efeito inibitório de substâncias que aumentam os níveis intracelulares dos nucleotídeos cíclicos
• Beneficiário: Fernanda Loureiro de Andrade Orsi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/16105-0 - Caracterização do risco de fenômenos tromboembólicos na COVID-19
• Beneficiário: Andréa Coy Canguçu
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica