| Texto completo | |
| Autor(es): Mostrar menos - |
Coy-Cangucu, Andrea
;
Locachevic, Gisele A.
;
Mariolano, Joao Carlos S.
;
Soares, Kaio Henrique De O.
;
Oliveira, Jose Diogo
;
Vaz, Camila De Oliveira
;
Vieira-Damiani, Gislaine
;
Mazetto, Bruna
;
Annichino-Bizzacchi, Joyce Maria
;
De Paula, Erich V.
;
Orsi, Fernanda A.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS; v. 29, p. 10-pg., 2023-01-01. |
| Resumo | |
Thrombosis occurrence in coronavirus disease 2019 (COVID-19) has been mostly compared to historical cohorts of patients with other respiratory infections. We retrospectively evaluated the thrombotic events that occurred in a contemporary cohort of patients hospitalized between March and July 2020 for acute respiratory distress syndrome (ARDS) according to the Berlin Definition and compared those with positive and negative real-time polymerase chain reaction results for wild-type severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) using descriptive analysis. The association between COVID-19 and thrombotic risk was evaluated using logistic regression. 264 COVID-19-positive (56.8% male, 59.0 years [IQR 48.6-69.7], Padua score on admission 3.0 [2.0-3.0]) and 88 COVID-19-negative patients (58.0% male, 63.7 years [51.2-73.5], Padua score 3.0 [2.0-5.0]) were included. 10.2% of non-COVID-19 and 8.7% of COVID-19 patients presented( )>=( )1 clinically relevant thrombotic event confirmed by imaging exam. After adjustment for sex, Padua score, intensive care unit stay, thromboprophylaxis, and hospitalization length, the odds ratio for thrombosis in COVID-19 was 0.69 (95% CI, 0.30-1.64). We, therefore, conclude that infection-induced ARDS carries an inherent thrombotic risk, which was comparable between patients with COVID-19 and other respiratory infections in our contemporary cohort. (AU) | |
| Processo FAPESP: | 16/14172-6 - Investigação de aspectos fisiopatológicos e novas abordagens terapêuticas em doenças tromboembólicas |
| Beneficiário: | Joyce Maria Annichino-Bizzacchi |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/12630-2 - Contribuição das redes extracelulares de neutrófilos (NETs) e da ativação plaquetária para a imunotrombose na COVID-19 e efeito inibitório de substâncias que aumentam os níveis intracelulares dos nucleotídeos cíclicos |
| Beneficiário: | Fernanda Loureiro de Andrade Orsi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/16105-0 - Caracterização do risco de fenômenos tromboembólicos na COVID-19 |
| Beneficiário: | Andréa Coy Canguçu |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |