| Texto completo | |
| Autor(es): |
Faiao-Flores, Fernanda
;
Quincoces Suarez, Jose Agustin
;
Pardi, Paulo Celso
;
Maria, Durvanei Augusto
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TUMOR BIOLOGY; v. 33, n. 3, p. 11-pg., 2012-06-01. |
| Resumo | |
This paper describes a new method for the preparation of sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate, DM-1, and 3-oxo-penta-1,4-dienyl-bis (2-methoxy-phenolate), DM-2. The aim of this work was to evaluate the antitumor effects of DM-1 in adjuvant chemotherapy for breast cancer treatment. Mice bearing mammary adenocarcinomas (Ehrlich ascites tumors) were treated with paclitaxel alone, DM-1 alone, and paclitaxel + DM-1. Tumor samples were used to perform cytological analysis by the Papanicolaou method and apoptosis analysis by annexin V and phosphorylated caspase 3. The paclitaxel + DM-1 group had decreased tumor areas and tumor volumes, and the frequency of metastasis was significantly reduced. This caused a decrease in cachexia, which is usually caused by the tumor. Furthermore, treatment with paclitaxel + DM-1 and DM-1 alone increased the occurrence of apoptosis up to 40% in tumor cells, which is 35% more than in the group treated with paclitaxel alone. This cell death was mainly caused through phosphorylated caspase 3 (11% increase in paclitaxel + DM-1 compared to the paclitaxel group), as confirmed by reduced malignancy criteria in the ascitic fluid. DM-1 emerges as a potential treatment for breast cancer and may act as an adjuvant in chemotherapy, enhancing antitumor drug activity with reduced side effects. (AU) | |
| Processo FAPESP: | 04/11351-0 - Sintese de heterociclos prenilados a partir de produtos naturais. |
| Beneficiário: | José Agustín Pablo Quincoces Suárez |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/59450-1 - Avaliacao da atividade antitumoral do composto sintetico dm-1 em ani mais portadores de tumor de ehrlich. |
| Beneficiário: | FERNANDA FAIÃO FLORES |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |