Dendritic cells and T lymphocytes interactions in a novel 3D system

Autor(es)

Steponavicius-Cruz, Karen ; Freitas, Vanessa Morais ; Barbuto, Jose Alexandre M. ; Bartolo, P ; Fernandes, P

• Tipo de documento: Artigo Científico
• Fonte: X INTERNATIONAL CONFERENCE ON STRUCTURAL DYNAMICS (EURODYN 2017); v. 59, p. 8-pg., 2013-01-01.

Resumo

We describe the interactions between monocyte-derived DCs, in different stages of maturation, with allogeneic T lymphocytes in a 3D system. Maturation of DCs increased their interaction time with T lymphocytes from 43 to 138 minutes. The average motility of T lymphocytes interacting or not with DCs was also affected, varying from 0.21 mu m-0.37 mu m/minute to 0.36 mu m-0.52 mu m/minute. These data indicate that this 3D Biotek (TM) scaffold enables interactions between lymphocytes and DCs at different stages of maturation and may be useful for the characterization of these interactions, the cellular subtypes and patterns of response induced. (C) 2013 The Authors. Published by Elsevier Ltd. (AU)

• Processo FAPESP: 10/18139-7 - Interações celulares em ambiente tridimensional entre células híbridas dendríticas-tumorais e linfócitos humanos: em busca de estratégias de aprimoramento de vacina antitumoral
• Beneficiário: Karen Steponavicius Piedade Cruz
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 09/54599-5 - Células dendríticas: elementos integrados do sistema imune - enfoque aplicado
• Beneficiário: Jose Alexandre Marzagão Barbuto
• Modalidade de apoio: Auxílio à Pesquisa - Temático