Role of serotonin 1A receptors in the median raphe nucleus on the behavioral consequences of forced swim stress

Autor(es)

Almeida, P. V. G. ; Trovo, M. C. ; Tokumoto, A. M. ; Pereira, A. C. ; Padovan, C. M.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHOPHARMACOLOGY; v. 27, n. 12, p. 7-pg., 2013-12-01.

Resumo

Despite the intense research on the neurobiology of stress, the role of serotonin (5-HT)1A receptors still remains to be elucidated. In the hippocampus, post-synaptic 5-HT1A receptors activation induces anxiolytic effects in animals previously exposed to stressful situations. However, little is known about somatodendritic 5-HT1A receptors in the median raphe nucleus (MRN). Therefore, the aim of this study was to investigate the role of 5-HT1A receptors located in the MRN in rats exposed to forced swim stress. After recovering from surgery, rats were forced to swim for 15 min in a cylinder. Intra-MRN injections of saline, 8-OH-DPAT (3 nmol/0.2 mu L) and/or WAY-100635 (0.3 nmol/0.2 mu L) were performed immediately before or after pre-exposure or 24 h later (immediately before test). Non-stressed rats received the same treatment 24 h or 10 min before test. Our data showed that 8-OH-DPAT increased latency to display immobility while decreasing time spent immobile in almost all experimental conditions. These effects were not prevented by previous treatment with WAY-100635. No effects of different treatments were described in non-stressed animals. Taken together, our data suggest that in addition to activation of 5-HT1A, 5-HT7 receptors may also be involved in the behavioural consequences of exposure to swim stress. (AU)

• Processo FAPESP: 07/07134-1 - Estresse, serotonina, glutamato e a via núcleo mediano da rafe-hipocampo: estudos comportamentais e sobre a neurogênese hipocampal adulta
• Beneficiário: Claudia Maria Padovan
• Modalidade de apoio: Auxílio à Pesquisa - Regular