| Texto completo | |
| Autor(es): |
Calvo, Adriana Maria
;
de Oliveira Prado, Mariel Tavares
;
Dionisio, Thiago Jose
;
Marques, Maria Paula
;
Brozoski, Daniel Thomas
;
Lanchote, Vera Lucia
;
Cardoso Faria, Flavio Augusto
;
Santos, Carlos Ferreira
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BRAZILIAN ORAL RESEARCH; v. 30, n. 1, p. 6-pg., 2016-01-01. |
| Resumo | |
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de Sao Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers. (AU) | |
| Processo FAPESP: | 13/18454-8 - Influência do genótipo do citocromo P450 (CYP2C9) na farmacocinética do piroxicam |
| Beneficiário: | Mariel Tavares de Oliveira Prado Bergamo |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 09/17851-8 - Influência do genótipo do citocromo P450 (CYP2C9) na eficácia clínica e farmacocinética do piroxicam após cirurgias de terceiros molares inferiores |
| Beneficiário: | Adriana Maria Calvo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |