Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

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dos Santos, Klinsmann Carolo ; Bueno, Bianca Guerra ; Pereira, Luana Ferreira ; Francisqueti, Fabiane Valentini ; Braz, Mariana Gobbo ; Bincoleto, Lahis Fernandes ; da Silva, Lilian Xavier ; Ferreira, Ana Lucia A. ; de Melo Stevanato Nakamune, Ana Claudia ; Chen, C. -Y. Oliver ; Blumberg, Jeffrey B. ; Correa, Camila Renata

• Tipo de documento: Artigo Científico
• Fonte: Evidence-based Complementary and Alternative Medicine; v. 2017, p. 9-pg., 2017-01-01.

Resumo

Theeffects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats. (AU)

• Processo FAPESP: 15/10626-0 - Inter-relação do gama-orizanol e ativação dos receptores Adipo- R1 e Adipo- R2: possível efeito na melhora da função renal associada à obesidade
• Beneficiário: Camila Renata Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/17364-8 - Efeito do extrato das folhas da Smallanthus sonchifolius (yacon) sobre as alterações metabólicas no músculo esquelético de ratos com Diabetes Mellitus Experimental
• Beneficiário: Bianca Guerra Bueno
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica