| Texto completo | |
| Autor(es): |
Russo, Fabiele Baldino
;
Baleeiro Beltrao-Braga, Patricia Cristina
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Biochemical and Biophysical Research Communications; v. 492, n. 4, p. 5-pg., 2017-10-28. |
| Resumo | |
The recent outbreak of ZIKV in Brazil called the attention of the world because the effects of viral infection in the brain under development in fetuses. Consequences of vertical infection comprise brain malformation, especially microcephaly, eye and musculoskeletal abnormalities, among others. In adults, outcomes of infection include meningoencephalitis and Guillain-Barre Syndrome. Recent data specific suggest that neural progenitor cells are the main targets of ZIKV infection, causing massive cellular death and impairment in the neurogenesis process. Here we review the fetal and adult brain damage after ZIKV exposure, exploring models to study the mechanisms underlying the pathways related to microcephaly and cell death. (C) 2017 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 14/17766-9 - Abordagem sistêmica no estudo da permissividade do Anticarsia gemmatalis múltiplo nucleopoliedrovírus (AgMNPV) |
| Beneficiário: | Paolo Marinho de Andrade Zanotto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/18703-2 - O papel do eixo triptofano - Kinureninas na regulação da resposta imune através de receptores de glutamato tipo NMDA na encefalomielite experimental auto-imune e na lesão por isquemia e reperfusão cerebral |
| Beneficiário: | Jean Pierre Schatzmann Peron |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |