Thyroid hormone actions on male reproductive system of teleost fish

Autor(es)

Tovo-Neto, Aldo ; Rodrigues, Maira da Silva ; Habibi, Hamid R. ; Nobrega, Rafael Henrique

• Tipo de documento: Artigo Científico
• Fonte: General and Comparative Endocrinology; v. 265, p. 7-pg., 2018-09-01.

Resumo

Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis. In general a positive correlation has been shown between THs and fish reproductive status; where THs are associated with testicular development, growth and maturation. Recently, the molecular mechanisms underlying the role of THs in spermatogenesis have been unraveled in zebrafish testis. THs promote germ cell proliferation and differentiation by increasing a stimulatory growth factor of spermatogenesis produced by Sertoli cells. In addition, THs enhanced the gonadotropin-induced androgen release in zebrafish testis. Next to their functions in the adult testis, THs are involved in the gonadal sex differentiation through modulating sex-related gene expression, and testicular development via regulation of Sertoli cell proliferation. In conclusion, this mini-review showed that THs modulate the male reproductive system during the different life stages of fish. The physiological and molecular mechanisms showed a link between the thyroid and reproduction, suggesting a possibly co-evolution and interdependence of these two systems. (AU)

• Processo FAPESP: 17/09218-0 - Efeitos da insuficiência do hormônio tireoidiano induzida pelo metilmazol em zebrafish (Danio rerio)
• Beneficiário: Aldo Tovo Neto
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/07620-7 - Banco de espermatogônias tronco em peixes para conservação do genótipo de espécies ameaçadas e de interesse econômico
• Beneficiário: Rafael Henrique Nóbrega
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/16280-5 - Controle endócrino e molecular envolvidos na diferenciação gonadal de zebrafish (Danio rerio)
• Beneficiário: Aldo Tovo Neto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/15793-7 - Efeitos do hipotireoidismo na função testicular de Danio rerio e relação dos hormônios tireoidianos com o hormônio folículo estimulante (Fsh)
• Beneficiário: Maira da Silva Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Mestrado